P14.20 Local control an overall survival after frameless LINAC radiosurgery: a single center experience
| Autor: | Oliver Oehlke, Marianne Schmucker, Angelika Bilger, F. Frenzel, R. Wiehle, Anca L. Grosu, Carsten Nieder, Dušan Milanović |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Cancer Research
medicine.medical_specialty medicine.diagnostic_test business.industry LINAC radiosurgery medicine.medical_treatment Magnetic resonance imaging Single Center Radiosurgery Radiation therapy Radiation necrosis Oncology medicine Medical physics Neurology (clinical) Progression-free survival business Nuclear medicine POSTER PRESENTATIONS Fixation (histology) |
| Zdroj: | Neuro-Oncology. 19:iii106-iii106 |
| ISSN: | 1523-5866 1522-8517 |
| DOI: | 10.1093/neuonc/nox036.405 |
| Popis: | Introduction: Stereotactic radiosurgery (SRS) has been increasingly advocated for 1-3 small brain metastases. Goal of this study was to evaluate the clinical results in patients with brain metastases treated with SRS using a thermoplastic mask non-invasive fixation system and image-guided treatment. MATERIAL AND METHODS: In this single-institution study 48 patients with 77 brain metastases were treated between February 2012 and January 2014. The head fixation was realized using a BrainLAB thermoplastic mask. The prescribed dose was 20 Gy or 18 Gy as a single dose. The SRS were performed with a True Beam STX Novalis Radiosurgery LINAC (Varian Medical Systems). The verification of positioning was done using the BrainLAB ExacTrac ® X-ray 6D system and cone-beam CT. Results: In 69 of 77 (89.6%) treated brain metastases the follow-up was documented on MR imaging performed every 3 months. In 7/69 (10.1%) brain metastases local failure was diagnosed with a mean follow-up time of 10.7 months (range 1-43 months). Estimated 1-year local control was 83.1%. Median progression free survival (PFS) was 3.7 months, largely due to distant brain relapse. A GTV of ≤ 2.0 cm3 was significantly associated with a better PFS than a GTV > 2.0 cm3. We observed 2 cases of radiation necrosis diagnosed by histology after surgical resection. No other cases of severe side effects (CTACE≥3) were observed. CONCLUSION: In our experience local control after frameless (ringless) LINAC based SRS with mean follow-up of 10.7 months is 89.9%. Without the invasive head fixation radiotherapy is more comfortable for the patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|