Diabetes associated risk for mortality increases with time among first stroke survivors - Findings from the Israeli National Stroke Registry
| Autor: | Amit Zamir, David Tanne, Yael Hershkovitz, Havi Murad, Inbar Zucker, Natan M. Bornstein, Carmit Libruder, Efrat Zamir |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Sociodemographic Factors Anemia Endocrinology Diabetes and Metabolism Population Endocrinology Risk Factors Internal medicine Diabetes mellitus Internal Medicine Diabetes Mellitus Medicine Humans Registries Survivors Risk factor Israel education Stroke Ischemic Stroke Proportional Hazards Models education.field_of_study Proportional hazards model business.industry Hazard ratio medicine.disease Population study Female business |
| Zdroj: | Journal of diabetes and its complications. 35(10) |
| ISSN: | 1873-460X |
| Popis: | Background Diabetes is a major risk factor for ischemic stroke and may affect post-stroke survival. Previous large scale studies of long-term post-stroke survival are limited and most of them excluded older patients from the study population. Objectives To compare the risk factors and sociodemographic characteristics between first ischemic stroke cases with and without diabetes and to assess the mortality risk associated with diabetes. Methods Using population-based National Stroke Registry in Israel, all patients hospitalized for a first event of ischemic stroke between the years 2014-2018 were followed for all-cause mortality. Chi-square analysis was used to compare the differences in risk factors, sociodemographic profile and cumulative mortality between patients with and without diabetes. Cox proportional hazards models were used to estimate the hazard ratio for mortality in selected timeframes. Results Among 41,639 patients with a first event of ischemic stroke, 44.5% were previously diagnosed with diabetes. Diabetic patients were more likely to be males, members of the Arab ethnic group, with lower socioeconomic status and a higher prevalence of cardiovascular comorbidities, anemia, leukocytosis and abnormal kidney function. Diabetes was associated with a higher mortality risk in the first year and long term, but not in the first month following stroke. Diabetes-associated mortality risk interacted with time and age, was higher in younger age and increased with time. Conclusions Our findings suggest that diabetes is associated with a higher prevalence of comorbidities among patients with first ischemic stroke and with a higher risk for mortality in the mid and long term, which is more profound in younger age. |
| Databáze: | OpenAIRE |
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