Skeletal muscle phosphate metabolism abnormalities in volume-overload experimental heart failure
| Autor: | C. Ribout, P. M. Mertes, J. M. Escanye, J. Robert, Etienne Aliot, J. P. Villemot, Faiez Zannad, B. L'Herbier, C. Michel, Z. Chati |
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| Rok vydání: | 1994 |
| Předmět: |
Male
High-energy phosphate medicine.medical_specialty Magnetic Resonance Spectroscopy Phosphocreatine Physiology Volume overload Vena Cava Inferior Blood volume Motor Activity Biology digestive system Phosphates chemistry.chemical_compound Gastrocnemius muscle Adenosine Triphosphate Arteriovenous Shunt Surgical Atrial natriuretic peptide Physiology (medical) Internal medicine medicine Animals Aorta Abdominal Rats Wistar Muscle Skeletal Heart Failure Blood Volume Hemodynamics Skeletal muscle Hydrogen-Ion Concentration medicine.disease Electric Stimulation digestive system diseases Rats Kinetics Endocrinology medicine.anatomical_structure chemistry Heart failure Cardiology and Cardiovascular Medicine |
| Zdroj: | American Journal of Physiology-Heart and Circulatory Physiology. 267:H2186-H2192 |
| ISSN: | 1522-1539 0363-6135 |
| DOI: | 10.1152/ajpheart.1994.267.6.h2186 |
| Popis: | We studied skeletal muscle phosphate metabolism abnormalities to examine their contribution at an early stage of congestive heart failure (CHF) in rats with aortocaval fistula (ACF) 4 wk after the procedure. In a group of 26 rats (13 with ACF and 13 sham operated), we assessed the degree of CHF. The ACF produced a significant rise in heart weight and plasma atrial natriuretic peptide. In a second group of 26 rats (13 ACF and 13 sham operated), we performed 31P-magnetic resonance spectroscopy in the gastrocnemius muscle during motor activity produced by electrical stimulation. The rate of phosphocreatine depletion, expressed by its initial slope, was higher in the ACF rats compared with controls (0.078 +/- 0.01 vs. 0.041 +/- 0.007; P < 0.03). pH and ATP decreased and phosphodiesters increased in all rats during electrical stimulation, with no difference between ACF rats and controls. The kinetics of phosphocreatine recovery were not different between ACF rats and controls. Together with previous studies, our present results suggest that muscle metabolism abnormalities in CHF may vary according to the experimental model and may be observed early in the course of the disease. |
| Databáze: | OpenAIRE |
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