A problem of pattern recognition in the automatic analysis of chromosomes: locating the centromere
| Autor: | G. Gallus, N. Montanaro, Maccacaro Ga |
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| Rok vydání: | 1968 |
| Předmět: |
Electronic Data Processing
business.industry Computers Medicine (miscellaneous) Chromosome Pattern recognition Karyotype Optical density Parallel Chromosomes Pattern Recognition Automated Karyotyping Centromere Pattern recognition (psychology) Humans Point (geometry) Artificial intelligence business Mathematics |
| Zdroj: | Computers and biomedical research, an international journal. 2(2) |
| ISSN: | 0010-4809 |
| Popis: | A program has been worked out to locate by computer the centromere on digitalized images of chromosomes. The basic criteria of the program (called FOSCAN) consist of: 1. (1) Scanning the digitalized chromosome along parallel lines in a suitable direction selected in such a way as to be nearly perpendicular to the mean direction of the chromosome arms. 2. (2) Selecting one, or possibly more, zones of convergence of the arms. 3. (3) Searching for the centromere in these zones and locating it as the minimum point of a suitable function of the optical density. 4. (4) If no minimum point is found, the centromere is located by means of a method of maximum incremental ratio. The examination of four digitalized cells—making a total of 184 chromosomes—resulted in 165 correct centromere locations (89.67%). The wrong locations occurred chiefly in small chromosomes (group F-G), while in all chromosomes of groups A and B the program gave correct results. |
| Databáze: | OpenAIRE |
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