Permeability of Ibuprofen in the Form of Free Acid and Salts of L-Valine Alkyl Esters from a Hydrogel Formulation through Strat-M™ Membrane and Human Skin
| Autor: | Łukasz Kucharski, Ewa Janus, Marta Markowska, Adam Klimowicz, Joanna Klebeko, Piotr Bargiel, Piotr Prowans, Anna Nowak, Jan Petriczko, Norbert Czapla, Paula Ossowicz-Rupniewska, Wiktoria Duchnik, Urszula Adamiak-Giera |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Technology
Franz cell diffusion Human skin Article Celugel® medicine General Materials Science Transdermal Microscopy QC120-168.85 Chromatography Chemistry QH201-278.5 Penetration (firestop) transdermal delivery system Permeation Ibuprofen Engineering (General). Civil engineering (General) TK1-9971 Membrane Descriptive and experimental mechanics Self-healing hydrogels Drug delivery derivatives of ibuprofen Electrical engineering. Electronics. Nuclear engineering human skin TA1-2040 Strat-M™ medicine.drug |
| Zdroj: | Materials, Vol 14, Iss 6678, p 6678 (2021) Materials Volume 14 Issue 21 |
| ISSN: | 1996-1944 |
| Popis: | This paper aimed to evaluate the effect of vehicle and chemical modifications of the structure of active compounds on the skin permeation and accumulation of ibuprofen [IBU]. In vitro permeation experiments were performed using human abdominal skin and Strat-M™ membrane. The HPLC method was used for quantitative determinations. The formulations tested were hydrogels containing IBU and its derivatives and commercial gel with ibuprofen. The results obtained indicate that Celugel® had an enhancing effect on the skin penetration of IBU. The average cumulative mass of [IBU] after 24 h permeation test from Celugel® formulation through human skin was over 3 times higher than for the commercial product. Three ibuprofen derivatives containing [ValOiPr][IBU], [ValOPr][IBU], and [ValOBu][IBU] cation were evaluated as chemical penetration enhancers. The cumulative mass after 24 h of penetration was 790.526 ± 41.426, 682.201 ± 29.910, and 684.538 ± 5.599 μg IBU cm−2, respectively, compared to the formulation containing unmodified IBU-429.672 ± 60.151 μg IBU cm−2. This study demonstrates the perspective of the transdermal hydrogel vehicle in conjunction with the modification of the drug as a potential faster drug delivery system. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|