Selective upregulation and amplification of the lysyl oxidase like-4 (LOXL4) gene in head and neck squamous cell carcinoma
| Autor: | Jan Bernd Weise, Petra Ambrosch, Katalin Csiszar, Jürgen Hedderich, Tibor Görögh, Stefan Gottschlich, Claudia Holtmeier, Markus Hoffmann, Pierre Rudolph |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male Immunocytochemistry Isochromosome Lysyl oxidase In situ hybridization Biology Pathology and Forensic Medicine Protein-Lysine 6-Oxidase Cell Line Tumor medicine Carcinoma Humans In Situ Hybridization Fluorescence Aged medicine.diagnostic_test Chromosomes Human Pair 10 Middle Aged Blotting Northern medicine.disease Immunohistochemistry Head and neck squamous-cell carcinoma Extracellular Matrix Up-Regulation Enzyme Activation Head and Neck Neoplasms Cell culture Case-Control Studies Cytogenetic Analysis Carcinoma Squamous Cell Cancer research Female Amino Acid Oxidoreductases Fluorescence in situ hybridization |
| Zdroj: | The Journal of Pathology. 212:74-82 |
| ISSN: | 1096-9896 0022-3417 |
| Popis: | Members of the lysyl oxidase family (LOX) are copper and lysyl-tyrosine quinone cofactor-containing amine oxidases that are important for the assembly and maintenance of components of the extracellular matrix. Our previous results demonstrated that a novel member, LOXL4, is overexpressed in head and neck squamous cell carcinoma (HNSCC) compared to normal squamous epithelium. Results of the current study showed overexpression of the LOXL4 transcript in 74% (46 of 62) of invasive HNSCC tumours and 90% of both primary and metastatic HNSCC cell lines. Significant correlation was found between LOXL4 expression and local lymph node metastases versus primary tumour types (p |
| Databáze: | OpenAIRE |
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