Maternal exposure to GOS/inulin mixture prevents food allergies and promotes tolerance in offspring in mice

Autor: Michel Neunlist, Philippe Aubert, Laure Castan, Faouzi Braza, Julie Chesné, Antoine Magnan, Marie Bodinier, Grégory Bouchaud
Přispěvatelé: unité de recherche de l'institut du thorax UMR1087 UMR6291 (ITX), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Seventh Framework Programme (FP7/2007-2013) under REA grant agreement no 624910, European Project: 267196,EC:FP7:PEOPLE,FP7-PEOPLE-2010-COFUND,AGREENSKILLS(2012), Unité de recherche de l'institut du thorax (ITX-lab), The Enteric Nervous System in gut and brain disorders [U1235] (TENS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE)
Jazyk: angličtina
Rok vydání: 2016
Předmět:
0301 basic medicine
Allergy
[SDV]Life Sciences [q-bio]
Oligosaccharides
MESH: Dietary Supplements
MESH: Inulin
medicine.disease_cause
Mice
chemistry.chemical_compound
Allergen
MESH: Pregnancy
Pregnancy
wheat
Immunology and Allergy
Medicine
MESH: Animals
Intestinal Mucosa
MESH: Maternal Exposure
2. Zero hunger
Inulin
3. Good health
Maternal Exposure
Prenatal Exposure Delayed Effects
MESH: Permeability
Allergic response
MESH: Intestinal Mucosa
gut
Female
Food Hypersensitivity
MESH: Lactation
MESH: Immune Tolerance
Offspring
Immunology
Permeability
MESH: Prenatal Exposure Delayed Effects
03 medical and health sciences
Th2 Cells
Food allergy
MESH: Th2 Cells
Immune Tolerance
microbiota
Animals
Lactation
Weaning
MESH: Microbiota
MESH: Mice
business.industry
medicine.disease
immunity
Disease Models
Animal
030104 developmental biology
chemistry
Dietary Supplements
MESH: Food Hypersensitivity
symptoms
MESH: Disease Models
Animal
business
MESH: Oligosaccharides
MESH: Female
Zdroj: Allergy
Allergy, Wiley, 2016, Equipe 6, 71 (1), pp.68--76. ⟨10.1111/all.12777⟩
Allergy, 2016, Equipe 6, 71 (1), pp.68--76. ⟨10.1111/all.12777⟩
ISSN: 0105-4538
1398-9995
DOI: 10.1111/all.12777⟩
Popis: International audience; BACKGROUND: Food allergies affect 4-8% of children and are constantly on the rise, thus making allergies a timely issue. Most importantly, prevention strategies are nonexistent, and current therapeutic strategies have limited efficacy and need to be improved. One alternative to prevent or reduce allergies, particularly during infancy, could consist of modulating maternal immunity and microbiota using nondigestible food ingredients, such as prebiotics. For this purpose, we studied the preventive effects of prebiotics in Balb/c mothers during pregnancy and breastfeeding on food allergy development in offspring mice. METHODS: After weaning, the offspring from mothers that were exposed to GOS/inulin mixture or fed a control diet were intraperitoneally sensitized to wheat proteins to induce a systemic allergic response and orally exposed to the same allergen. Immunological, physiological, and microbial parameters were analyzed. RESULTS: GOS/inulin mixture diet modified the microbiota of mothers and their offspring. Offspring from mothers that received GOS/inulin prebiotics were protected against food allergies and displayed lower clinical scores, specifically of IgE and histamine levels, compared to offspring from mothers fed a control diet. Moreover, GOS/inulin supplementation for the mother resulted in stronger intestinal permeability in the offspring. Enhancement of the regulatory response to allergic inflammation and changes in the Th2/Th1 balance toward a dampened Th2 response were observed in mice from GOS/inulin mixture-exposed mothers. CONCLUSION: The treatment of pregnant and lactating mice with nondigestible GOS/inulin prebiotics promotes a long-term protective effect against food allergies in the offspring.
Databáze: OpenAIRE
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