Microglia and Other Myeloid Cells in Central Nervous System Health and Disease
| Autor: | Adithya Gopinath, Wolfgang J. Streit, Habibeh Khoshbouei, Anthony Collins |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Central Nervous System Chemokine Myeloid Neuroimmunomodulation Central nervous system Inflammation Monocytes 03 medical and health sciences 0302 clinical medicine Special Section on Sexual Dimorphism in Neuroimmune Cells Alzheimer Disease Medicine Animals Humans Myeloid Cells Pharmacology Innate immune system biology Microglia business.industry Macrophages Neurodegeneration Parkinson Disease medicine.disease 030104 developmental biology medicine.anatomical_structure Immunology biology.protein Molecular Medicine Bone marrow medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | J Pharmacol Exp Ther |
| Popis: | Mononuclear macrophages derived from the bone marrow (myeloid cells) are key cellular components of the innate immune system in different organs. In this mini-review, we are focused on both brain and blood macrophages known as microglia and monocytes, respectively. We provide a succinct summary of the cells9 functions under both normal and pathological conditions, with particular reference to common neurodegenerative disorders, Alzheimer9s and Parkinson9s disease. SIGNIFICANCE STATEMENT In this mini-review we aim to summarize available literature on microglial and myeloid involvement in CNS disease, directing the reader towards relevant and translatable interpretations of myeloid cell function in CNS health and neurodegeneration. |
| Databáze: | OpenAIRE |
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