Rapid tumor regression and induction of tumor-regressing activity in serum by various immune-modulating agents
| Autor: | Hidemasa Ogawa, Takehiko Kunimoto, Yasuo Kita, Kazuo Nitta, Morihiro Kohno, Keiki Sato, Hiroyasu Baba, Sinjiro Hashimoto |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Pharmacology
chemistry.chemical_classification Mice Inbred ICR medicine.medical_specialty Ratón Immunology Lentinan Biological activity Biology Polysaccharide Mice chemistry.chemical_compound Immune system Endocrinology chemistry Polysaccharides Internal medicine medicine Tumor regression Cancer research Animals Immunotherapy Sarcoma 180 Gene Glucan |
| Zdroj: | International Journal of Immunopharmacology. 8:569-572 |
| ISSN: | 0192-0561 |
| DOI: | 10.1016/0192-0561(86)90027-5 |
| Popis: | A rapid decrease in the number of tumor cells from S180 tumors was caused by several antitumor polysaccharides including the β(1–3)glucans lentinan and TAK-N and a mannoglucan MGA, but not by those lacking antitumor activity. MGA was demonstrated to induce potent tumor-regressing activity in the serum of tumor-bearing mice similar to that reported previously to be induced after an injection of CM-TAK, a carboxymethylated β(1–3)glucan. It is probable that the induction of rapid regression of established tumors is a phenomenon common to antitumor polysaccharides and some microbiological products and that the tumor-regressing factor in the serum underlies a common mechanism. |
| Databáze: | OpenAIRE |
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