Frequency of the minor BCR-ABL (e1;a2) transcript oncogene in a Mexican population with adult acute lymphoblastic leukaemia
| Autor: | Emma Mendoza-García, K.A. Nacho-Vargas, Juan Collazo-Jaloma, Etta Rozen-Fuller, Adolfo Martínez-Tovar, Christian Omar Ramos-Peñafiel, J.J. Kassack-Ipiña, Jorge Zamora-Domínguez, Enrique Miranda-Peralta, I. Mendoza-Salas, Irma Olarte-Carrillo |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Oncology
medicine.medical_specialty Philadelphia chromosome BCR-ABL oncogene Internal medicine hemic and lymphatic diseases medicine Leucemia aguda linfóblastica Cromosoma Philadelphia lcsh:R5-920 Oncogene business.industry Acute lymphoblastic leukaemia General Medicine European population medicine.disease Mexican population Reverse transcription polymerase chain reaction Oncogén BCR-ABL Cohort Cancer research Population study Lymphoblastic leukaemia business lcsh:Medicine (General) |
| Zdroj: | Revista Médica del Hospital General de México, Vol 78, Iss 3, Pp 119-123 (2015) |
| ISSN: | 0185-1063 |
| Popis: | Background The minor BCR-ABL ( e1;a2 ) transcript oncogene is the most common genetic alteration in adults with acute lymphoblastic leukaemia (ALL). It is associated with a poor prognosis. Aim To determine the frequency of minor BCR-ABL ( e1;a2 ) transcript oncogene expression in ALL patients in Mexico. Material and methods A cohort of 411 patients with de novo ALL were tested for the oncogene using reverse transcription polymerase chain reaction (RT-PCR). Results The oncogene was found in 14% ( n = 57) of the study population. Mean age was 29 years, and 53% were male. Median leucocyte count was 53 × 10 3 μl. Conclusion Prevalence of BCR-ABL expression by RT-PCR has not previously been reported in Mexico. Our laboratory found a higher prevalence than that reported in Latin-American series, but lower than that reported for the European population. |
| Databáze: | OpenAIRE |
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