The synthesis and evaluation of cyclic ureas as HIV protease inhibitors: Modifications of the P1/P1′ residues

Autor:	Beverly C. Cordova, R. M. Klabe, M. M. Rayner, L. T. Bacheler, Steven P. Seitz, Mona Patel, Susan Erickson-Viitanen
Rok vydání:	1998
Předmět:	Stereochemistry medicine.medical_treatment Clinical Biochemistry Pharmaceutical Science Antiviral Agents Biochemistry Chemical synthesis Structure-Activity Relationship Residue (chemistry) HIV Protease Drug Discovery medicine Urea Structure–activity relationship HIV Protease Inhibitor Molecular Biology chemistry.chemical_classification Protease Molecular Structure biology Chemistry Organic Chemistry HIV Azepines HIV Protease Inhibitors In vitro Kinetics Enzyme Enzyme inhibitor biology.protein Molecular Medicine Indicators and Reagents
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 8:823-828
ISSN:	0960-894X
DOI:	10.1016/s0960-894x(98)00119-x
Popis:	Two series of cyclic ureas modified at the P1/P1′ residue were prepared and evaluated for HIV protease inhibition and whole cell antiviral activity. Compounds 8b, 10 (3- and 4-pyridylmethyl analogs) and 6b (4-methoxy analog) showed significant improvement in antiviral activity relative to lead compounds DMP323 and DMP 450.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::887c56be7a43fdaec25a94eb9deddde4 https://doi.org/10.1016/s0960-894x(98)00119-x Zobrazit plný text záznamu Full Text from ScienceDirect