Serum dietary fatty acids and coronary heart disease risk - A nested case-control-study within the CARLA cohort
Autor: | Maria Elena Lacruz, J. Schumann, Alexander Kluttig, Daniel Medenwald |
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Rok vydání: | 2018 |
Předmět: |
Male
Time Factors Endocrinology Diabetes and Metabolism Population Medicine (miscellaneous) Physiology 030209 endocrinology & metabolism Coronary Disease Disease 030204 cardiovascular system & hematology Risk Assessment 03 medical and health sciences 0302 clinical medicine Risk Factors Germany Fatty Acids Omega-3 Medicine Humans Prospective Studies education Aged chemistry.chemical_classification Aged 80 and over education.field_of_study Nutrition and Dietetics business.industry Incidence Fatty acid Middle Aged Protective Factors Prognosis chemistry Ageing Case-Control Studies Nested case-control study Cohort Female Diet Healthy Cardiology and Cardiovascular Medicine business Biomarkers Polyunsaturated fatty acid Cohort study |
Zdroj: | Nutrition, metabolism, and cardiovascular diseases : NMCD. 29(2) |
ISSN: | 1590-3729 |
Popis: | Background and Aims Diet is known to play a decisive role in the development of coronary heart disease (CHD). One factor believed to decrease lifetime risk of CHD is the consumption of omega-3 fatty acids. Yet, conclusive evidence regarding the potential cardioprotective effects of fatty acids is far from being reached. The present study aimed to provide further evidence on the association of serum fatty acid profiles with CHD risk. Methods and Results The CARdio-vascular Disease, Living and Ageing in Halle study (CARLA study) is an observational cohort study comprising an older adult's general population with a high level of cardiovascular risk factors. In a matched case–control design the serum fatty acid concentrations of 73 subjects with an incident fatal or nonfatal CHD event were compared to 146 controls matched for sex and age. Our data show that the participants of the CARLA study are underserved in unsaturated fatty acids with respect to current dietary recommendations. In addition, the ratio of omega-6 to omega-3 fatty acids was determined to be 8:1 which underlines the consumption of a Western-style diet enriched in omega-6 fatty acids. There were no significant differences in fatty acid patterns between cases and controls. Thus, no clear association of particular serum fatty acid levels with cardiovascular risk was found. Conclusion Our results support the conclusion that in populations with a homogenous low level of omega-3 polyunsaturated fatty acids consumption, serum fatty acid levels are not associated with CHD risk. |
Databáze: | OpenAIRE |
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