Overlapping morphological and functional properties between M4 and M5 intrinsically photosensitive retinal ganglion cells
| Autor: | Tiffany M. Schmidt, Takuma Sonoda, Yudai Okabe |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male Retinal Ganglion Cells genetic structures Population Biology Dendritic branch Article Color opponency Visual processing 03 medical and health sciences Mice 0302 clinical medicine medicine Animals education education.field_of_study General Neuroscience Intrinsically photosensitive retinal ganglion cells eye diseases 030104 developmental biology medicine.anatomical_structure Retinal ganglion cell Mouse Retina Soma Female sense organs Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | J Comp Neurol |
| ISSN: | 1096-9861 |
| Popis: | Multiple retinal ganglion cell (RGC) types in the mouse retina mediate pattern vision by responding to specific features of the visual scene. The M4 and M5 melanopsin-expressing, intrinsically photosensitive retinal ganglion cell (ipRGC) subtypes are two RGC types that are thought to play major roles in pattern vision. The M4 ipRGCs overlap in population with ON-alpha RGCs, while M5 ipRGCs were recently reported to exhibit opponent responses to different wavelengths of light (color opponency). Despite their seemingly distinct roles in visual processing, previous reports have suggested that these two populations may exhibit overlap in their morphological and functional properties, which calls into question whether these are in fact distinct RGC types. Here, we show that M4 and M5 ipRGCs are distinct morphological classes of ipRGCs, but that they cannot be exclusively differentiated based on color opponency and dendritic morphology as previously reported. Instead, we find that M4 and M5 ipRGCs can only be distinguished based on soma size and number of dendritic branch points in combination with SMI-32 immunoreactivity. These results have important implications for clearly defining retinal ganglion cell types and their roles in visual behavior. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text