Imaging Perfusion Deficits in Ischemic Heart Disease with Susceptibility-Enhanced T2-Weighted MRI: Preliminary Human Studies
| Autor: | Robert M. Weisskoff, Pekka Niemi, Henry Gewirtz, Garth M. Beache, Sarah F. Kulke, David A. Chesler, Thomas J. Brady, Terrance A. Campbell, Howard L. Kantor, Bruce R. Rosen |
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| Rok vydání: | 1998 |
| Předmět: |
Adult
Male Gadolinium Myocardial Infarction Myocardial Ischemia Biomedical Engineering Biophysics Ischemia Contrast Media chemistry.chemical_element Infarction Perfusion scanning Sensitivity and Specificity Coronary artery disease Dysprosium medicine Humans Radiology Nuclear Medicine and imaging Aged medicine.diagnostic_test business.industry Magnetic resonance imaging Middle Aged Pentetic Acid Image Enhancement medicine.disease Magnetic Resonance Imaging chemistry Feasibility Studies Thallium Female Artifacts business Nuclear medicine Perfusion |
| Zdroj: | Magnetic Resonance Imaging. 16:19-27 |
| ISSN: | 0730-725X |
| DOI: | 10.1016/s0730-725x(97)00219-1 |
| Popis: | Aim: This feasibility study explores relative myocardial perfusion characterization with an investigational T 2 / T 2 ∗ contrast agent. Methods: Dysprosium-DTPA bis (methylamide) was administered peripherally in six patients with thallium defects. Rest and stress multi-section, gated, T 2 -weighted images were acquired with a 1.5 T echo-planar imager. Change in transverse relaxation rate was calculated in four segments for each subject. Results: Magnetic resonance (MR) identified five of five instances of ischemia or infarction, at a dose of agent (0.25 mmol/kg) that was comparable to that currently used with clinically approved gadolinium agents. Injection at twice this dose resulted in saturation of the signal change, and the one ischemic segment corresponding to the higher dose was not identified by MR. MR was negative in two segments which, on final diagnosis, were determined to manifest thallium attenuation artifact. Conclusion: MR perfusion imaging with high susceptibility agents has the potential to characterize myocardial perfusion deficits. |
| Databáze: | OpenAIRE |
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