Adenoid cystic carcinoma of the maxillary sinus with gradual histologic transformation to high-grade adenocarcinoma: a comparative report with dedifferentiated carcinoma
| Autor: | Sachiko Kaji, Aya Sakurai, Shogo Katsuda, Yoshimichi Ueda, Katsuaki Sato, Takayuki Nojima, Yoshimaro Ishikawa |
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| Rok vydání: | 2004 |
| Předmět: |
Male
medicine.medical_specialty Pathology Lung Neoplasms Maxillary sinus Adenoid cystic carcinoma Maxillary Sinus Neoplasms Adenocarcinoma behavioral disciplines and activities Pathology and Forensic Medicine Cyclin D1 Fatal Outcome medicine Carcinoma Humans Molecular Biology Aged biology CD117 business.industry Liver Neoplasms S100 Proteins Anatomical pathology Muscle Smooth Cell Biology General Medicine medicine.disease Carcinoma Adenoid Cystic Immunohistochemistry Actins stomatognathic diseases medicine.anatomical_structure nervous system biology.protein Disease Progression Keratins Histopathology Tumor Suppressor Protein p53 business human activities psychological phenomena and processes |
| Zdroj: | Virchows Archiv : an international journal of pathology. 448(2) |
| ISSN: | 0945-6317 |
| Popis: | We report a unique case of adenoid cystic carcinoma (ACC) of the maxillary sinus, with gradual histologic transformation from lower-grade ACC (cribriform and tubular types) to high-grade adenocarcinoma (HGA) showing a sequential histologic spectrum via solid-type ACC. A 74-year-old man presented with swelling and mild pain of the right cheek. CT scan showed a mass measuring approximately 4 cm, with marked bone destruction in the right maxillary sinus. A surgically resected specimen revealed that the tumor was comprised of three different components: HGA and solid-type ACC in the central portion and lower-grade ACC in the periphery. The tumor was discriminated from a dedifferentiated carcinoma or hybrid tumor. Autopsy specimens also demonstrated both solid-type ACC and HGA components in the lung and spleen. Immunohistochemically, positive staining of p53 protein was detected on both solid-type ACC and HGA cells, but cyclin D1 and HER2/neu was only seen in HGA cells. Solid-type ACC cells were immunoreactive for CD117 (c-kit), but lower-grade ACC and HGA cells were negative. This case suggests that the overexpression of CD117, p53 protein, cyclin D1, and HER2/neu might be involved in the progression from lower-grade ACC to solid-type ACC and HGA. |
| Databáze: | OpenAIRE |
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