Toxicity and Reproductive Parameters Impairment of Cypermethrin in Male Guinea Pig (Cavia porcellus)
| Autor: | Arthénice Jemima Nounamo Guiekep, A. Teguia, Edouard Akono Nantia, Augustave Kenfack, Astride Martine Megnimeza Tsambou, Chancel Patrick Nelo, Bertin Narcisse Vemo, Ferdinand Ngoula, Claude Cedric Njieudeu Ngaleu, Ferry Nana Yidjeu |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
media_common.quotation_subject
0211 other engineering and technologies Cavia 02 engineering and technology 010501 environmental sciences reproduction impairment 01 natural sciences Cypermethrin Guinea pig Andrology lcsh:Agriculture chemistry.chemical_compound male guinea pig lcsh:Agriculture (General) Testosterone 0105 earth and related environmental sciences media_common 021110 strategic defence & security studies Creatinine biology lcsh:S toxicity biology.organism_classification Sperm lcsh:S1-972 chemistry cypermethrin Toxicity testosterone Reproduction |
| Zdroj: | Turkish Journal of Agriculture: Food Science and Technology, Vol 6, Iss 2, Pp 130-135 (2018) |
| Popis: | Cypermethrin is a large spectrum action insecticide, globally employed to control pests in agriculture and some human and domestic animals ectoparasites. This study aimed to evaluate its toxicity and reproduction impairment in male guinea pig. Forty adult male guinea pigs were divided into 4 groups and orally submitted to 0, 92, 137.5 and 275 mg/kg body weight/day for 90 days. The weight of the liver increased significantly, while that of kidneys decreased significantly in treated animals compared to controls. Serum concentrations of creatinine, urea, ALAT, ASAT, total cholesterol, prostatic acid phosphatase increased significantly, while the testicular total protein level decreased significantly in groups given the insecticide relatively to the control. The testes weight, libido, serum level of testosterone, mobility, sperm count and the percentage of spermatozoa with entire plasma membrane decreased significantly in animals exposed to cypermethrin with reference to controls. The percentages of abnormal spermatozoa increased significantly in animals submitted to 137.5 or 275 mg/kg body weight (bw) of cypermethrin compared to control ones. On the testis histological sections of pesticide-treated animals, immature germinal cells were observed in the lumen of seminiferous tubules. Cypermethrin was toxic in male guinea pig and damaged reproductive parameters. |
| Databáze: | OpenAIRE |
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