Diet quality is associated with circulating C-reactive protein but not irisin levels in humans
| Autor: | Cynthia Davis, Judith A. Crowell, Kyung Hee Park, Lesya Zaichenko, Patricia R Peter, Christos S. Mantzoros |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Leptin Male medicine.medical_specialty Mediterranean diet Endocrinology Diabetes and Metabolism Healthy eating Diet Mediterranean Article Body Mass Index Endocrinology Waist–hip ratio Internal medicine Electric Impedance medicine Humans Aged biology business.industry C-reactive protein Feeding Behavior Middle Aged medicine.disease Obesity Fibronectins C-Reactive Protein Cross-Sectional Studies Diet quality Body Composition biology.protein Female Energy Intake business Body mass index Biomarkers |
| Zdroj: | Metabolism. 63:233-241 |
| ISSN: | 0026-0495 |
| DOI: | 10.1016/j.metabol.2013.10.011 |
| Popis: | Adherence to a healthy diet has been shown to decrease the incidence of obesity and associated comorbidities. C-reactive protein (CRP) is an established inflammatory marker and irisin was recently identified as a molecule which may play a role in energy regulation and obesity but whether diet alters irisin levels remains unknown. We aimed to investigate the association between circulating irisin, leptin, and CRP levels and dietary quantity and quality using the Alternate Healthy Eating Index (AHEI) and the Alternate Mediterranean Diet Score (aMED).The study evaluated dietary data and biomarker levels of 151 participants between 2009 and 2011 (71 male vs. 80 female, over 35 years old, obese 43.7%). AHEI and aMED scores were calculated based on data derived from self-administered 110-item food-frequency questionnaires estimating usual nutrient intake over the past year. Cross-sectional associations between dietary quantity, quality, body composition by bioelectric impedance, and biomarker levels including irisin, leptin, and CRP after fasting were assessed.CRP, but not irisin, was negatively correlated with AHEI (r=-0.34) and aMED (r=-0.31). Irisin was positively correlated with BMI (r=0.22), fat mass (r=0.21), waist circumference (r=0.24), waist-hip ratio (r=0.20), leptin (r=0.32), and CRP (r=0.25). Participants with the highest AHEI scores tended to have 11.6% lower concentrations of irisin (P for trend =0.09), but they were not significant after adjustment for potential confounders. Better diet quality was associated with lower CRP concentrations (P for trend=0.02) in multivariate model. Percentage of energy from carbohydrate was inversely associated with CRP.Unlike CRP, irisin is not associated with dietary quality or quantity. |
| Databáze: | OpenAIRE |
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