A Multicenter Study on Long-Term Outcomes After Lung Transplantation Comparing Donation After Circulatory Death and Donation After Brain Death

Autor: E.A. van de Graaf, Michiel E. Erasmus, Jos A. Bekkers, W. van der Bij, R C A Meijer, Rogier A.S. Hoek, C. Van De Wauwer, Erik A M Verschuuren, V. van Suylen, Bart Luijk
Přispěvatelé: Cardiovascular Centre (CVC), Groningen Institute for Organ Transplantation (GIOT), Pulmonary Medicine, Cardiothoracic Surgery
Rok vydání: 2017
Předmět:
Graft Rejection
Male
donors and donation
medicine.medical_treatment
DONORS
030204 cardiovascular system & hematology
030230 surgery
Cardiovascular System
0302 clinical medicine
lung transplantation/pulmonology
030202 anesthesiology
PERFUSION
Immunology and Allergy
Pharmacology (medical)
organ transplantation in general
donors and donation: donation after brain death (DBD)
Lung
pulmonology
CARDIOCIRCULATORY DEATH
Netherlands
dysfunction
Incidence (epidemiology)
Middle Aged
respiratory system
Circulatory death
practice
TIME
Treatment Outcome
Pulmonology
medicine.anatomical_structure
Donation
HEART
Female
Cardiology and Cardiovascular Medicine
Adult
Pulmonary and Respiratory Medicine
Brain Death
medicine.medical_specialty
Tissue and Organ Procurement
Primary Graft Dysfunction
organ procurement and allocation
Context (language use)
clinical research/practice
03 medical and health sciences
patient survival
INTERNATIONAL-SOCIETY
BRONCHIOLITIS-OBLITERANS-SYNDROME
Internal medicine
medicine
lung transplantation
Humans
Lung transplantation
donation after brain death (DBD)
Transplantation
business.industry
donors and donation: donation after circulatory death (DCD)
Survival Analysis
lung (allograft) function
Surgery
respiratory tract diseases
Clinical research
clinical research
lung (allograft) function/dysfunction
Propensity score matching
CARDIAC-DEATH
EXPERIENCE
business
bronchiolitis obliterans (BOS)
donation after circulatory death (DCD)
Zdroj: American Journal of Transplantation, 17(10), 2679-2686. Wiley
American Journal of Transplantation, 17(10), 2679. Blackwell Publishing Asia Pty Ltd
American Journal of Transplantation, 17(10), 2679-2686. Wiley-Blackwell Publishing Ltd
ISSN: 1600-6143
1600-6135
Popis: The implementation of donation after circulatory death category 3 (DCD3) was one of the attempts to reduce the gap between supply and demand of donor lungs. In the Netherlands, the total number of potential lung donors was greatly increased by the availability of DCD3 lungs in addition to the initial standard use of donation after brain death (DBD) lungs. From the three lung transplant centers in the Netherlands, 130 DCD3 recipients were one-to-one nearest neighbor propensity score matched with 130 DBD recipients. The primary end points were primary graft dysfunction (PGD), posttransplant lung function, freedom from chronic lung allograft dysfunction (CLAD), and overall survival. PGD did not differ between the groups. Posttransplant lung function was comparable after bilateral lung transplantation, but seemed worse after DCD3 single lung transplantation. The incidence of CLAD (p = 0.17) nor the freedom from CLAD (p = 0.36) nor the overall survival (p = 0.40) were significantly different between both groups. The presented multicenter results are derived from a national context where one third of the lung transplantations are performed with DCD3 lungs. We conclude that the long-term outcome after lung transplantation with DCD3 donors is similar to that of DBD donors and that DCD3 donation can substantially enlarge the donor pool.
Databáze: OpenAIRE
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