Double-blind multicenter trial on a new medium molecular weight glycosaminoglycan current therapeutic effects and perspectives for clinical use
| Autor: | A. Strano, O. Carandente, Calabrò A, Gino Avellone, R. Antonini, Antonio Capurso, Giovanni Davì, Francesco Resta, Renato Fellin, Gaetano Crepaldi, A. Bucci, Alessandro Ventura, G. C. Descovich, Paolo Rubba, A. Vicari, Mario Mancini, Novo S, L. Lalloni, Elmo Mannarino, Alfredo Postiglione, Antonio Pinto, Rossi A, Antonio Vittorino Gaddi, Guido Pozza, S. Rimondi, A. M. Mogavero, Umberto Senin, Giovanni Ciuffetti |
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| Rok vydání: | 1990 |
| Předmět: |
Adult
Male medicine.medical_specialty Lipoproteins Blood viscosity Hyperlipidemias Hyperlipoproteinemia Type V Fibrinogen Placebo Gastroenterology Hyperlipoproteinemia Type II Double-Blind Method Erythrocyte Deformability Internal medicine Multicenter trial Humans Multicenter Studies as Topic Medicine Triglycerides Aged Glycosaminoglycans Hypolipidemic Agents Hypertriglyceridemia Clinical Trials as Topic business.industry Vascular disease Therapeutic effect Middle Aged Blood Viscosity medicine.disease Sulodexide Crossover study Surgery Cholesterol Female Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Atherosclerosis. 81:233-243 |
| ISSN: | 0021-9150 |
| Popis: | The ability of glycosaminoglycans to bind to a wide number of biologically active macromolecules has already been investigated. Recent clinical trials on the possible therapeutic benefits of glycosaminoglycans must be placed in perspective, even if they appear to be particularly encouraging, especially as regards the glycosaminoglycan effects on certain coagulation factors. A multicenter, medium-term, double-blind, crossover trial was performed by several Italian Lipid Clinics to determine whether administration of a medium molecular weight glycosaminoglycan (Sulodexide) has a significant clinical effect. Patients affected by peripheral vascular disease and/or hyperlipidemia (type IIa, IIb and IV) were submitted to a 4-week wash-out period, followed by parenteral Sulodexide (S) or placebo (P) administration for 2 weeks, another 2 week wash-out period, parenteral crossover drug or P administration for 2 weeks and, finally, oral S administration for 6 months. Sulodexide lowered plasma viscosity and plasma fibrinogen in all patients. There was also a drop in triglycerides together with a rise in apo A-I and HDL-C in type IV hyperlipoproteinemics, whereas there was no significant effect on total or LDL-plasma cholesterol in type IIa and IIb patients. Moreover, there was a percent increase in peak flow and rest flow in the lower limbs of peripheral vascular disease patients. No side effects or intolerance phenomena were detected. The results indicate that Sulodexide administration may be useful in long-term treatment of patients with peripheral vascular disease and a concomitant increase in plasma triglycerides and/or fibrinogen and/or viscosity. |
| Databáze: | OpenAIRE |
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