If started early in life, metformin treatment increases life span and postpones tumors in female SHR mice
| Autor: | Irina G. Popovich, Tatiana E. Poroshina, Irina G. Kovalenko, Margarita L. Tyndyk, Vladimir N. Anisimov, Tatiana S. Piskunova, Peter A. Egormin, Anna V. Semenchenko, Lev M. Berstein, Maria N. Yurova, Mark A. Zabezhinski |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
Aging mice Epithelial-Mesenchymal Transition endocrine system diseases medicine.medical_treatment Longevity Breast Neoplasms biomarkers of aging Life Expectancy Biomarkers of aging Internal medicine Hyperinsulinemia Medicine Animals Humans Hypoglycemic Agents Genetic Predisposition to Disease Enzyme Inhibitors Maximum life span Cellular Senescence Estrous cycle Life span business.industry Insulin Ribosomal Protein S6 Kinases TOR Serine-Threonine Kinases Adenylate Kinase Cancer nutritional and metabolic diseases Cell Biology life extension spontaneous carcinogenesis medicine.disease Metformin Endocrinology Disease Progression Female business medicine.drug Research Paper age of initiation Signal Transduction |
| Zdroj: | Aging (Albany NY) |
| ISSN: | 1945-4589 |
| Popis: | Hyperglycemia and hyperinsulinemia accelerate both aging and cancer. Antidiabetic biguanides such as metformin decrease glucose, insulin and IGF-1 level. Metformin increases lifespan and prevents cancer in mice, although its effects vary, depending on mice strain and gender. Here we showed that chronic treatment of female outbred SHR mice with metformin started at the age of 3, 9 or 15 months decreased body temperature and postponed age-related switch-off of estrous function. Surprisingly, metformin did not affect levels of serum cholesterol, triglycerides, glucose and insulin. Treatment with metformin started at the age of 3 months increased mean life span by 14% and maximum life span by 1 month. The treatment started at the age of 9 months insignificantly increased mean life span by only 6%, whereas the treatment started at the age of 15 months failed to increase life span. The mean life span of tumor-free mice was increased by 21% in ‘the youngest group’, by 7% in ‘middle-aged group’ and in contrast was reduced by 13% in ‘the oldest group’. When started at the age of 3 and 9 months, metformin delayed the first tumor detection by 22% and 25%, correspondingly. Thus, in female SHR mice, metformin increased life span and postponed tumors when started at the young and middle but not at the old age. In contrast, metformin improves reproductive function when started at any age. |
| Databáze: | OpenAIRE |
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