Impaired hippocampal place cell dynamics in a mouse model of the 22q11.2 deletion
| Autor: | Zhenrui Liao, Andres Grosmark, Fraser T. Sparks, Patrick Kaifosh, Joseph A. Gogos, Anastasia Diamantopoulou, Attila Losonczy, Nathan Danielson, John C. Bowler, Jeffrey D. Zaremba |
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| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Place cell Hippocampus Mice Transgenic Biology Hippocampal formation Article Mice Random Allocation 03 medical and health sciences 0302 clinical medicine DiGeorge Syndrome medicine Animals Humans Learning Episodic memory Recall General Neuroscience Cognitive flexibility Cognition medicine.disease Mice Inbred C57BL Disease Models Animal 030104 developmental biology Place Cells Schizophrenia Female Goals Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Nature Neuroscience. 20:1612-1623 |
| ISSN: | 1546-1726 1097-6256 |
| DOI: | 10.1038/nn.4634 |
| Popis: | Hippocampal place cells represent the cellular substrate of episodic memory. Place cell ensembles reorganize to support learning but must also maintain stable representations to facilitate memory recall. Despite extensive research, the learning-related role of place cell dynamics in health and disease remains elusive. Using chronic two-photon Ca2+ imaging in hippocampal area CA1 of wild-type and Df(16)A+/− mice, an animal model of 22q11.2 deletion syndrome, one of the most common genetic risk factors for cognitive dysfunction and schizophrenia, we found that goal-oriented learning in wild-type mice was supported by stable spatial maps and robust remapping of place fields toward the goal location. Df(16)A+/− mice showed a significant learning deficit accompanied by reduced spatial map stability and the absence of goal-directed place cell reorganization. These results expand our understanding of the hippocampal ensemble dynamics supporting cognitive flexibility and demonstrate their importance in a model of 22q11.2-associated cognitive dysfunction. |
| Databáze: | OpenAIRE |
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