Effect of indomethacin on opioid-induced gastric protection in cold-restrained stress
| Autor: | Giovanna M. Scoto, Concetta Spadaro, Edmondo Scoto, Carmela Parenti, R. Arrigo-Reina |
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| Rok vydání: | 1991 |
| Předmět: |
Male
Narcotics medicine.medical_specialty Enkephalin Indomethacin Prostaglandin General Biochemistry Genetics and Molecular Biology Lesion chemistry.chemical_compound Stress Physiological Internal medicine D-Ala(2) MePhe(4) Met(0)-ol-enkephalin medicine Gastric mucosa Animals Stomach Ulcer General Pharmacology Toxicology and Pharmaceutics Opioid peptide Morphine Chemistry Stomach Rats Inbred Strains General Medicine Rats medicine.anatomical_structure Endocrinology Opioid Gastric Mucosa Prostaglandins medicine.symptom Injections Intraperitoneal medicine.drug |
| Zdroj: | Life Sciences. 48:867-871 |
| ISSN: | 0024-3205 |
| DOI: | 10.1016/0024-3205(91)90032-7 |
| Popis: | Morphine and the synthetic opioid met-enkephalin analog [ D-Ala 2 , MePhe 4 ,Met(0) 5 ol ] enkephalin (FK 33–824) injected intraperitoneally to rats at doses of 5–20 and 0.5–2 mg/kg respectively showed a protective effect on gastric lesion induced by cold-restraint stress. This protective effect was abolished by pretreatment with indomethacin. This suggests a role for prostaglandins in the protection, induced by opioids, of the gastric mucosa against the development of stress-induced ulcers. |
| Databáze: | OpenAIRE |
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