Number of glomeruli in normal and hypertrophied kidneys of mice and guinea-pigs
| Autor: | A Courtalon, Alain Vandewalle, Farman N, M. Champion, J. P. Bonvalet, F. Wanstok |
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| Rok vydání: | 1977 |
| Předmět: |
Male
medicine.medical_specialty Physiology Guinea Pigs Kidney Glomerulus Biology urologic and male genital diseases Nephrectomy Muscle hypertrophy Mice Species Specificity Internal medicine medicine Animals Kidney urogenital system Age Factors Nephrons Unilateral nephrectomy Endocrinology medicine.anatomical_structure Contralateral kidney Normal growth Regression Analysis Female Research Article |
| Zdroj: | The Journal of Physiology. 269:627-641 |
| ISSN: | 0022-3751 |
| Popis: | 1. In mice and guinea-pigs, the number of glomeruli was counted in kidneys during normal growth and in hypertrophy induced by unilateral nephrectomy. 2. In mice, the number of glomeruli increased sharply during the first 2 weeks in life, and more slowly afterwards. Unilateral nephrectomy, when performed during this period of natural increase, induced the formation of supplementary nephrons in the contralateral kidney. 3. In guinea-pigs, the number of glomeruli was almost complete at birth. No evidence of a supplementary increase in the number of nephrons was found in hypertrophied kidneys following unilateral nephrectomy. 4. These results, together wit previous data obtained in the rat, suggest that the ability to induce new nephrons after unilateral nephrectomy in different species would depend more on the state of kidney maturity at birth than on differences in the renal mechanisms which lead to hypertrophy. |
| Databáze: | OpenAIRE |
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