Oil-in-water emulsion adjuvants for pediatric influenza vaccines: a systematic review and meta-analysis
| Autor: | Chia-Chen Chang, Yun-Jui Shih, Ying-Ying Lin, Yu-Ju Lin, Wen-Chi Hsieh, Yi-Hsuan Chen, Chian-Hui Hsu, Chang-Hsun Chen, Chiao-Ni Wen, Chi-Tai Fang |
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| Rok vydání: | 2020 |
| Předmět: |
Databases
Factual Science medicine.medical_treatment 030231 tropical medicine Orthomyxoviridae General Physics and Astronomy Antibodies Viral Paediatric research Article General Biochemistry Genetics and Molecular Biology law.invention 03 medical and health sciences 0302 clinical medicine Adjuvants Immunologic Randomized controlled trial law Influenza Human medicine Humans Adjuvants 030212 general & internal medicine lcsh:Science Child Multidisciplinary biology business.industry Immunogenicity Vaccination Statistics Immunity virus diseases Water General Chemistry biology.organism_classification Clinical trial Influenza Vaccines Meta-analysis Relative risk Antibody Formation Immunology lcsh:Q Emulsions Influenza virus business Oils Adjuvant |
| Zdroj: | Nature Communications Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020) |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/s41467-019-14230-x |
| Popis: | Standard inactivated influenza vaccines are poorly immunogenic in immunologically naive healthy young children, who are particularly vulnerable to complications from influenza. For them, there is an unmet need for better influenza vaccines. Oil-in-water emulsion-adjuvanted influenza vaccines are promising candidates, but clinical trials yielded inconsistent results. Here, we meta-analyze randomized controlled trials with efficacy data (3 trials, n = 15,310) and immunogenicity data (17 trials, n = 9062). Compared with non-adjuvanted counterparts, adjuvanted influenza vaccines provide a significantly better protection (weighted estimate for risk ratio of RT-PCR-confirmed influenza: 0.26) and are significantly more immunogenic (weighted estimates for seroprotection rate ratio: 4.6 to 7.9) in healthy immunologically naive young children. Nevertheless, in immunologically non-naive children, adjuvanted and non-adjuvanted vaccines provide similar protection and are similarly immunogenic. These results indicate that oil-in-water emulsion adjuvant improves the efficacy of inactivated influenza vaccines in healthy young children at the first-time seasonal influenza vaccination. Here, the authors meta-analyze clinical trials comparing adjuvanted and non-adjuvanted influenza vaccines in children and find that oil-in-water emulsion adjuvant improves the efficacy of inactivated influenza vaccines in healthy immunologically naive children. |
| Databáze: | OpenAIRE |
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