TRIM28 and the control of transposable elements in the brain
| Autor: | Per Ludvik Brattås, Marie E. Jönsson, Johan Jakobsson, Daniela A. Grassi |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Transposable element TRIM28 Tripartite Motif-Containing Protein 28 Biology Epigenesis Genetic 03 medical and health sciences 0302 clinical medicine Animals Humans Gene silencing Gene Regulatory Networks Epigenetics Molecular Biology Transcription factor Psychological repression Zinc finger Mechanism (biology) General Neuroscience Brain Cell biology Repressor Proteins 030104 developmental biology Gene Expression Regulation DNA Transposable Elements Neurology (clinical) 030217 neurology & neurosurgery Transcription Factors Developmental Biology |
| Zdroj: | Brain Research. 1705:43-47 |
| ISSN: | 0006-8993 |
| DOI: | 10.1016/j.brainres.2018.02.043 |
| Popis: | TRIM28 is an epigenetic co-repressor protein that mediates transcriptional silencing. TRIM28 participates, together with the large family of Kruppel-associated box domain zinc finger proteins (KRAB-ZFP) transcription factors, in the repression of transposable elements (TE). Recent advances indicate that TRIM28-based repression of TEs occurs in the mammalian brain and may provide beneficial effects through the regulation of transcriptional networks. Here, we provide an overview of TRIM28-related functions, highlighting the role of controlling TEs in neural progenitor cells and discuss how this mechanism may have contributed to the evolution of the complex human brain. Finally, we outline future considerations for the field. |
| Databáze: | OpenAIRE |
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