Adenosine as a Marker and Mediator of Cardiovascular Homeostasis: A Translational Perspective
| Autor: | Saleh Alghofaili, F. Daniel Ramirez, Richard G. Jung, Paul Boland, Etienne Couture, Rebecca Rochman, Rob S. Beanlands, Jeffrey A. Marbach, Juan J Russo, Chantal Gaudet, Trevor Simard, Pietro Di Santo, Mohammad Ali Faraz, Benjamin Hibbert, Pouya Motazedian, Alisha Labinaz, Kiran Sarathy, Ian Pitcher |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Adenosine 030204 cardiovascular system & hematology Cardiovascular System 03 medical and health sciences 0302 clinical medicine Mediator Medicine Homeostasis Humans Pharmacology business.industry Purinergic receptor Hematology General Medicine Adenosine receptor Biomarker 030104 developmental biology Molecular Medicine Cardiology and Cardiovascular Medicine business Nucleoside Neuroscience Adenosine A2B receptor medicine.drug |
| Zdroj: | Cardiovascularhematological disorders drug targets. 19(2) |
| ISSN: | 2212-4063 |
| Popis: | Adenosine, a purine nucleoside, is produced broadly and implicated in the homeostasis of many cells and tissues. It signals predominantly via 4 purinergic adenosine receptors (ADORs) – ADORA1, ADORA2A, ADORA2B and ADORA3 in addition to non-ADOR mediated effects. Through these signaling mechanisms, adenosine exerts effects on numerous cell types crucial to maintaining vascular homeostasis, especially following vascular injury. Both in vitro and in vivo models have provided considerable insights into adenosine signaling and identified targets for therapeutic intervention. Numerous pharmacologic agents have been developed that modulate adenosine signaling, both through design as specific ADOR agonists and antagonists and as offtarget effects of existing anti-platelet medications. Despite this, adenosine has yet to be firmly established as either a therapeutic or a prognostic tool in clinical medicine to date. Herein, we provide a bench-to-bedside review of adenosine biology, highlighting the key considerations for further translational development of this promising molecule. |
| Databáze: | OpenAIRE |
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