MiR-92b and miR-9/9* are specifically expressed in brain primary tumors and can be used to differentiate primary from metastatic brain tumors
| Autor: | Einat Sitbon, Iris Barshack, Ana Tobar, Zvi Bentwich, Shlomit Gilad, Anat Schlosberg, Nitzan Rosenfeld, Netta Sion-Vardy, Shai Rosenwald, Dvora Nass, Eti Meiri, Eran Elyakim, Hila Cholakh, Yael Spector, Hagit Kuker, Hilla Tabibian-Keissar, Oleg Kharenko, Gila Lithwick Yanai, Hadas Gibori |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Pathology medicine.medical_specialty Gene Expression Biology Malignancy medicine.disease_cause Sensitivity and Specificity Pathology and Forensic Medicine Metastasis Diagnosis Differential microRNA medicine Biomarkers Tumor Molecular diagnostics Humans Neoplasm Metastasis Research Articles Oligonucleotide Array Sequence Analysis Brain Neoplasms Reverse Transcriptase Polymerase Chain Reaction General Neuroscience Tumor classification Cancer medicine.disease Primary tumor MicroRNA expression Gene expression profiling body regions MicroRNAs ROC Curve Area Under Curve embryonic structures Neurology (clinical) Stem cell Carcinogenesis |
| Zdroj: | Brain Pathology (Zurich, Switzerland) |
| ISSN: | 1750-3639 |
| Popis: | A recurring challenge for brain pathologists is to diagnose whether a brain malignancy is a primary tumor or a metastasis from some other tissue. The accurate diagnosis of brain malignancies is essential for selection of proper treatment. MicroRNAs are a class of small non-coding RNA species that regulate gene expression; many exhibit tissue-specific expression and are misregulated in cancer. Using microRNA expression profiling, we found that hsa-miR-92b and hsa-miR-9/hsa-miR-9* are over-expressed, specifically in brain primary tumors, as compared to primary tumors from other tissues and their metastases to the brain. By considering the expression of only these two microRNAs, it is possible to distinguish between primary and metastatic brain tumors with very high accuracy. These microRNAs thus represent excellent biomarkers for brain primary tumors. Previous reports have found that hsa-miR-92b and hsa-miR-9/hsa-miR-9* are expressed more strongly in developing neurons and brain than in adult brain. Thus, their specific over-expression in brain primary tumors supports a functional role for these microRNAs or a link between neuronal stem cells and brain tumorigenesis. |
| Databáze: | OpenAIRE |
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