Reduction of Plasma Lipids, Lipoproteins, and Apoproteins by Dietary Fish Oils in Patients with Hypertriglyceridemia
| Autor: | William S. Harris, D W Rothrock, D R Illingworth, William E. Connor, Beverley E. Phillipson |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Adult
Male Hyperlipoproteinemias medicine.medical_specialty Diet therapy Lipoproteins Linoleic acid Saturated fat Blood lipids Hyperlipoproteinemia Type V Lipoproteins VLDL Biology Hyperlipoproteinemia Type II chemistry.chemical_compound Fish Oils Internal medicine medicine Humans Triglycerides Aged chemistry.chemical_classification Triglyceride Hypertriglyceridemia Fatty acid General Medicine Middle Aged Fish oil medicine.disease Dietary Fats Lipids Lipoproteins LDL Cholesterol Endocrinology chemistry Female Apoproteins |
| Zdroj: | New England Journal of Medicine. 312:1210-1216 |
| ISSN: | 1533-4406 0028-4793 |
| DOI: | 10.1056/nejm198505093121902 |
| Popis: | Dietary fish oils, which are rich in omega-3 fatty acids, have been reported to reduce plasma lipid levels in normolipidemic subjects. We examined the effects of fish oil in 20 hypertriglyceridemic patients: 10 with Type IIb hyperlipidemia and 10 with Type V. These patients were put on three diets differing primarily in fatty acid composition and fat content. The control diet contained a fatty acid mixture typical of a low-fat therapeutic diet (ratio of polyunsaturated to saturated fat, 1.4), the fish-oil diet contained omega-3 fatty acids, and the vegetable-oil diet was rich in the omega-6 fatty acid, linoleic acid. Each diet was followed for four weeks. In the Type IIb group, the fish-oil diet led to decreases in both plasma cholesterol (-27 per cent) and triglyceride (-64 per cent), as compared with the control diet. Very-low-density lipoproteins (VLDLs) were also reduced markedly. The vegetable-oil diet had much less effect. With fish oil, the Type V group had marked decreases in total cholesterol and triglyceride levels (-45 and -79 per cent, respectively). VLDL levels were dramatically lowered, as were apoprotein E levels. The vegetable-oil diet (unlike the fish-oil diet) produced a rapid and significant rise in plasma triglyceride levels. We conclude that fish oils and fish may be useful components of diets for the treatment of hypertriglyceridemia. |
| Databáze: | OpenAIRE |
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