Hodgkin's Disease Occurring in Monocytoid B-Cell Clusters
| Autor: | Khalil Sheibani, Renee L. Mohrmann, Bharat N. Nathwani, Russell K. Brynes |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Pathology
medicine.medical_specialty Disease Monocytes Immunophenotyping Antigens CD polycyclic compounds Humans Medicine Monocytoid B-Cell skin and connective tissue diseases neoplasms Lymph node Aged Aged 80 and over B-Lymphocytes Hodgkin s business.industry General Medicine Middle Aged bacterial infections and mycoses medicine.disease Hodgkin Disease medicine.anatomical_structure Reed–Sternberg cell bacteria Immunohistochemistry Female Lymph Nodes Lymph business |
| Zdroj: | American Journal of Clinical Pathology. 95:802-808 |
| ISSN: | 1943-7722 0002-9173 |
| Popis: | The authors report three cases of Hodgkin's disease (HD) occurring in monocytoid B-cell (MBC) clusters within lymph nodes, a finding heretofore not published. MBC clusters were found mainly in a perisinusoidal and perifollicular distribution in all three cases. Within some of the MBC clusters of each case, small foci of overt necrosis were evident. Sternberg-Reed cells or their variants were found adjacent to all of these foci, as well as within some MBC clusters that were free of necrosis. These findings suggest that the presence of necrosis within MBC clusters has diagnostic utility. In two cases, evidence of HD was detected only within MBC clusters and nowhere else. In the third case, HD was found primarily within MBC clusters. These observations imply that HD arose within MBC clusters. Minimal involvement of lymph node by HD can occur within MBC clusters and should be recognized as such on the basis of morphologic features. The earlier a diagnosis of HD can be made, the better is the patient's outlook for survival. |
| Databáze: | OpenAIRE |
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