Response to Two Consecutive Protease Inhibitor Combination Therapy Regimens in a Cohort of HIV-1-infected Children
| Autor: | Fortino Solórzano, Veronica L. Palafox, Gerardo C. Palacios, Guillermo Vazquez, Maria T. Alvarez-Munoz, Guadalupe Miranda, Onofre Muñoz |
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| Rok vydání: | 2002 |
| Předmět: |
Microbiology (medical)
medicine.medical_specialty Adolescent Combination therapy Anti-HIV Agents HIV Infections Gastroenterology Drug Administration Schedule Cohort Studies Zidovudine Internal medicine medicine Humans Child Didanosine General Immunology and Microbiology business.industry Infant Lamivudine HIV Protease Inhibitors General Medicine Viral Load CD4 Lymphocyte Count Surgery Regimen Treatment Outcome Infectious Diseases Child Preschool HIV-1 RNA Viral Reverse Transcriptase Inhibitors Drug Therapy Combination Ritonavir business Viral load Saquinavir medicine.drug |
| Zdroj: | Scandinavian Journal of Infectious Diseases. 34:41-44 |
| ISSN: | 1651-1980 0036-5548 |
| DOI: | 10.1080/00365540110077047 |
| Popis: | The response to 2 consecutive protease inhibitor (P1) combination regimens was evaluated in a cohort of HIV-1-infected children. Twelve children, most of whom had been heavily treated, received a 3-drug treatment: saquinavir in hard gelatin capsules (SQVhgc) + zidovudine (ZDV) + didanosine. When this treatment failed it was replaced by a 4-drug regimen: ritonavir + SQVhgc + ZDV + lamivudine. A mild and temporary decrease in viral load (VL) was observed with the initial regimen (p = 0.22). Therapy failure occurred in 7 patients (58%) within 9 months and in another 3 (25%) within 9-18 months. The 7 children who failed within 9 months received the subsequent boosted regimen, leading to a significant and lasting reduction in VL (p = 0.001). None of the patients failed on the boosted regimen: 5/7 achieved a VL of400 copies/ml and 3/7 achieved a VL of50 copies/ml. Our results suggest that a 4-drug regimen including 2 PIs produces a better and more sustained response than a 3-drug regimen including only 1 PI, and that a good, sustained response is possible with subsequent boosted regimens even in heavily treated children. |
| Databáze: | OpenAIRE |
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