Tributyltin perturbs femoral cortical architecture and polar moment of inertia in rat
| Autor: | Dong Cheng, Hui Li, Wenhuan Yao, Mingjun Li, Shu’e Wang, Jiliang Si, Dongmei Guo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Polar moment of inertia chemistry.chemical_element Diseases of the musculoskeletal system 010501 environmental sciences Calcium 01 natural sciences Rats Sprague-Dawley 03 medical and health sciences chemistry.chemical_compound Inorganic phosphate Rheumatology Osteogenesis Bone Density Internal medicine Medicine Animals Orthopedics and Sports Medicine Femur 030304 developmental biology 0105 earth and related environmental sciences 0303 health sciences Micro-computed tomography Adipogenesis business.industry Bone geometry Research Cortical architecture Tributyltin X-Ray Microtomography Rats medicine.anatomical_structure Endocrinology RC925-935 chemistry Endocrine disruptor Bone marrow Trialkyltin Compounds business Corn oil |
| Zdroj: | BMC Musculoskeletal Disorders BMC Musculoskeletal Disorders, Vol 22, Iss 1, Pp 1-9 (2021) |
| ISSN: | 1471-2474 |
| Popis: | Background Tributyltin, a well-known endocrine disruptor, is widely used in agriculture and industry. Previous studies have shown that tributyltin could cause deleterious effects on bone health by impairing the adipo-osteogenic balance in bone marrow. Methods To investigate further the effects of tributyltin on bone, weaned male SD rats were treated with tributyltin (0.5, 5 or 50 μg·kg− 1) or corn oil by gavage once every 3 days for 60 days in this study. Then, we analyzed the effects of tributyltin on geometry, the polar moment of inertia, mineral content, relative abundances of mRNA from representative genes related to adipogenesis and osteogenesis, serum calcium ion and inorganic phosphate levels. Results Micro-computed tomography analysis revealed that treatment with 50 μg·kg− 1 tributyltin caused an obvious decrease in femoral cortical cross sectional area, marrow area, periosteal circumference and derived polar moment of inertia in rats. However, other test results showed that exposure to tributyltin resulted in no significant changes in the expression of genes detected, femoral cancellous architecture, ash content, as well as serum calcium ion and inorganic phosphate levels. Conclusions Exposure to a low dose of tributyltin from the prepubertal to adult stage produced adverse effects on skeletal architecture and strength. |
| Databáze: | OpenAIRE |
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