Blockade of muscarinic acetylcholine receptor by scopolamine impairs the memory formation of filial imprinting in domestic chicks (Gallus Gallus domesticus)
| Autor: | Eiko Fujita, Koichi J. Homma, Naoya Aoki, Chihiro Mori, Toshiya Matsushima, Shinji Yamaguchi, Toshiyuki Fujita |
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| Rok vydání: | 2019 |
| Předmět: |
Telencephalon
Scopolamine Muscarinic Antagonists Biology 03 medical and health sciences Behavioral Neuroscience 0302 clinical medicine Alzheimer Disease Muscarinic acetylcholine receptor medicine Animals Learning Imprinting (psychology) 030304 developmental biology Receptor Muscarinic M3 0303 health sciences Memory Disorders Behavior Animal Cerebrum Antagonist Muscarinic acetylcholine receptor M3 Muscarinic acetylcholine receptor M1 Disease Models Animal medicine.anatomical_structure Precocial Neuroscience Chickens 030217 neurology & neurosurgery Acetylcholine Locomotion medicine.drug |
| Zdroj: | Behavioural brain research. 379 |
| ISSN: | 1872-7549 |
| Popis: | Filial imprinting in precocial birds is a useful model for studying memory formation in early learning. The intermediate medial mesopallium (IMM) in the dorsal telencephalon is one of the critical brain regions where the releases of several neurotransmitters increase after the start of imprinting training. Among the increased neurotransmitters, the role of acetylcholine in imprinting has remained unclear. Acetylcholine in the mammalian brain plays an important role in encoding new memories. The muscarinic acetylcholine receptor subtype 1 (M1 receptor) and subtype 3 (M3 receptor) in the hippocampus and cortex of mammalian brain have been shown to be necessary for memory encoding. In this study, we examined whether the imprinting acquisition in chick can be impaired by injecting muscarinic acetylcholine receptor (mAChR) antagonist scopolamine into the bilateral IMM. We show that the injection of scopolamine decreased the preference for the imprinting object in the test, but did not affect the number of approaches to the imprinting object during training. Immunoblotting and immunohistochemistry revealed that M3 receptors were expressed in the IMM. Our data suggest that acetylcholine is involved in the memory formation of imprinting through M3 receptors in the IMM. The scopolamine-injected chicks may be useful as an animal model for dementia such as Alzheimer's disease. |
| Databáze: | OpenAIRE |
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