Endothelial protein C receptor polymorphisms and risk of myocardial infarction
| Autor: | Francisco Marín, Pilar Medina, Esther Zorio, Francisco España, Rogier M. Bertina, Vanessa Roldán, Joaquín Rueda, Silvia Navarro, Amparo Santamaría, Amparo Estellés, Recava Thrombosis Groups, Javier Corral |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Male medicine.medical_specialty Genotype Myocardial Infarction Receptors Cell Surface Antigens CD Risk Factors Internal medicine medicine Humans Myocardial infarction Allele Receptor Alleles Endothelial protein C receptor Polymorphism Genetic Hematology business.industry Haplotype Endothelial Protein C Receptor Odds ratio Middle Aged medicine.disease Enzyme Activation Endocrinology Female business Protein C medicine.drug |
| Zdroj: | Haematologica. 93:1358-1363 |
| ISSN: | 1592-8721 0390-6078 |
| DOI: | 10.3324/haematol.13066 |
| Popis: | Background Haplotypes A1 and A3 in the endothelial protein C receptor gene are tagged by the 4678G/C and 4600A/G polymorphisms, respectively, and have been reported to influence the risk of venous thromboembolism. We assessed whether these haplotypes modify the risk of premature myocardial infarction. Design and Methods We genotyped these polymorphisms in 689 patients with premature myocardial infarction and 697 control subjects. Activated protein C and soluble endothelial protein C receptor levels were also measured. Results After adjustment for other cardiovascular risk factors, A1 and A3 haplotypes protected against premature myocardial infarction (odds ratio 0.7, 95% CI 0.4–0.8, p =0.044 and 0.5, 0.3–0.6, p |
| Databáze: | OpenAIRE |
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