Endometrial Dating Method Detects Individual Maturation Sequences During the Secretory Phase
| Autor: | Matthias W. Beckmann, Rolf Behrens, Roxana M Popovici, Joachim Alfer, Amir Fattahi, Arndt Hartmann, Jürgen Krieg, Nathalie Bleisinger, Irmgard Classen-Linke, Ralf Dittrich |
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| Rok vydání: | 2020 |
| Předmět: |
Ovulation
Cancer Research medicine.drug_class Biopsy media_common.quotation_subject Estrogen receptor Biology General Biochemistry Genetics and Molecular Biology Andrology Endometrium 03 medical and health sciences 0302 clinical medicine Progesterone receptor medicine Humans Embryo Implantation Menstrual Cycle Progesterone Menstrual cycle media_common Pharmacology Embryo Embryo transfer Estrogen 030220 oncology & carcinogenesis Immunohistochemistry Female Receptors Progesterone Research Article |
| Zdroj: | In Vivo |
| ISSN: | 1791-7549 0258-851X |
| DOI: | 10.21873/invivo.11992 |
| Popis: | Background/aim This study assessed whether a new immunohistochemical dating method allows precise endometrial dating allowing optimal timing for embryo transfer. Patients and methods A novel method was used for endometrial dating, with parameters including menstrual cycle days, Noyes histological criteria, along with immunohistochemical expression pattern of estrogen and progesterone receptors and proliferation marker Ki-67. Endometrial maturation was analyzed on days +5 to +10 after ovulation or progesterone administration in 217 biopsies from 151 subfertile patients during the secretory phase. Results Endometrial maturation varied individually, occurring 1.68±1.67 days late. Comparison of histological maturation with clinical days after ovulation showed a delay of about 2 days. Conclusion Endometrial maturation requires 8 days, rather than the expected 6 days, to reach the histological mid-secretory phase. This is not a delay and is also seen in fertile patients. The new analysis method used is superior to that using Noyes criteria alone and provides a better basis for determining conditions for optimal timing of embryo transfers. |
| Databáze: | OpenAIRE |
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