Autoantibodies and Rheumatologic Manifestations in Hepatitis C Virus Infection
| Autor: | Enrico Fusaro, Clara Lisa Peroni, Simone Parisi, Angela Laganà, Richard Borrelli, Cristina Realmuto, Rosanna Degiovanni, Maria Chiara Ditto, Chiara Centanaro Di Vittorio, Marta Priora |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
myalgia
hepatitis C virus education.field_of_study General Immunology and Microbiology QH301-705.5 Population Arthritis Review Biology medicine.disease Cryoglobulinemia General Biochemistry Genetics and Molecular Biology Chronic infection Sicca syndrome auto-antibodies Immunology medicine Rheumatoid factor rheumatological manifestation medicine.symptom Biology (General) General Agricultural and Biological Sciences Vasculitis education |
| Zdroj: | Biology, Vol 10, Iss 1071, p 1071 (2021) Biology |
| ISSN: | 2079-7737 |
| Popis: | Simple Summary In patients with HCV, rheumatic manifestations are mostly mediated by immunological mechanisms, rather than being related to the viral infection of extrahepatic tissues. Molecular mimicry of viral antigens, chronic stimulation of B cells and a bystander effect are some of the mechanisms for the development of autoimmune phenomena and lymphoproliferative disorders; these conditions can either be clinical, merely serological or both. Among these patients, the occurrence of auto-antibodies is a finding strictly associated with a chronic infectious trigger since HCV has been proved to induce a B-mediated response shortly after the activation of the innate immune system. Given this scenario, a rheumatic disorder can be found as it might coexist with the HCV infection thus giving an overlap syndrome in some patients. Nevertheless, direct-acting antiviral therapies have largely demonstrated to reduce the damage stemming from both systemic inflammatory phenomena and a persistent immune activation by promoting an early viral eradication. Abstract HCV is a virus that can cause chronic infection which can result in a systemic disease that may include many rheumatologic manifestations such as arthritis, myalgia, sicca syndrome, cryoglobulinemia vasculitis as well as other non-rheumatological disorders (renal failure, onco-haematological malignancies). In this population, the high frequency of rheumatoid factor (45–70%), antinuclear (10–40%) and anticardiolipin (15–20%) antibodies is a B-cell mediated finding sustained by the infection. However, the possibility that a primitive rheumatic pathology may coexist with the HCV infection is not to be excluded thus complicating a differential diagnosis between primitive and HCV-related disorders. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|