Breast Cancer Incidence and Mortality in Relation to Hormone Replacement Therapy Use Among Postmenopausal Women: Results From a Prospective Cohort Study
| Autor: | Rong Chen, Yi Jiang, QinLi Xie |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Cancer Research medicine.medical_specialty medicine.drug_class Hormone Replacement Therapy medicine.medical_treatment Breast Neoplasms 03 medical and health sciences 0302 clinical medicine Breast cancer Risk Factors medicine Humans Prospective Studies Prospective cohort study Aged business.industry Proportional hazards model Obstetrics Incidence (epidemiology) Estrogen Replacement Therapy Hormone replacement therapy (menopause) Middle Aged medicine.disease Confidence interval Postmenopause 030104 developmental biology Oncology Receptors Estrogen Estrogen 030220 oncology & carcinogenesis Female Underweight medicine.symptom business Follow-Up Studies |
| Zdroj: | Clinical breast cancer. 22(2) |
| ISSN: | 1938-0666 |
| Popis: | Hormone replacement therapy (HRT) is associated with increased risk of breast cancer (BC), but little evidence assesses the effects of potential effect-modifiers on HRT-related BC. We sought to examine the relationship of different HRT types/method use and risk of BC in US postmenopausal women. In total, 689 BC cases and 81 BC deaths were identified during 372,210 person-years of follow-up. Cox regression and competing risk regression were used to estimate multivariable-adjusted hazards ratios (HRs) and 95% confidence intervals (95% CIs) by HRT status (never, former, current) for risk of BC incidence and mortality. The total current HRT use was associated with an increased risk of BC (HR current vs. never, 1.67; 95% CI, 1.33, 2.11), but did not associate with risk of death from BC (HR current vs. never, 0.85; 95% CI, 0.40, 1.78). Furthermore, underweight women (BMI 30 kg/m2, HR current vs never, 1.19; 95% CI, 0.73, 1.97). This study suggests that HRT use was associated with an altered risk of the occurrence of BC in the US postmenopausal women, especially for underweight women. |
| Databáze: | OpenAIRE |
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