Adapting liposomes for oral drug delivery
| Autor: | Zhongjian Chen, Wei Wu, Quangang Zhu, Jianping Qi, Haisheng He, Yi Lu |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
TPGS
tocopherol polyethylene glycol succinate Bioavailability SPC soy phosphatidylcholine PEG - Polyethylene glycol Review DMPC dimyristoyl phosphatidyl choline Pharmacology SGC sodium glycocholate PC phosphatidylcholine 0302 clinical medicine DC dendritic cells General Pharmacology Toxicology and Pharmaceutics Lipid bilayer STC sodium taurocholate 0303 health sciences Liposome Chemistry RES reticulo-endothelial FITC fluorescein isothiocyannate Tgel gelling temperature 030220 oncology & carcinogenesis Drug delivery DPPC dipalmitoyl phosphotidylcholine SDC sodium deoxycholate MRT mean residence time Drug carrier Stability SC sodium cholate Oral UEA 1 ulex europaeus agglutinin 1 rhEGF recombinant human epithelial growth factor Biocompatibility WGA wheat germ agglutinin AUC area under curve FAE follicle-associated epithelia Absorption 03 medical and health sciences PEG polyethylene glycol 030304 developmental biology MVL multivesicular liposomes GIT gastrointestinal tract lcsh:RM1-950 LUV large unilamellar vesicles lcsh:Therapeutics. Pharmacology APC antigen-presenting cell MLV multilamellar vesicles Tp phase transition temperature Liposomes BSA bovine serum albumin SUV small unilamellar vesicles Oral retinoid |
| Zdroj: | Acta Pharmaceutica Sinica B, Vol 9, Iss 1, Pp 36-48 (2019) Acta Pharmaceutica Sinica. B |
| ISSN: | 2211-3835 |
| DOI: | 10.1016/j.apsb.2018.06.005 |
| Popis: | Liposomes mimic natural cell membranes and have long been investigated as drug carriers due to excellent entrapment capacity, biocompatibility and safety. Despite the success of parenteral liposomes, oral delivery of liposomes is impeded by various barriers such as instability in the gastrointestinal tract, difficulties in crossing biomembranes, and mass production problems. By modulating the compositions of the lipid bilayers and adding polymers or ligands, both the stability and permeability of liposomes can be greatly improved for oral drug delivery. This review provides an overview of the challenges and current approaches toward the oral delivery of liposomes. Graphical abstract Despite the success of parenteral liposomes, oral delivery of liposomes is impeded by various barriers such as instability, poor permeability and mass production difficulties. By modulating bilayer compositions and decorating with polymers or ligands, both the stability and permeability of liposomes can be greatly improved, bettering liposomes for oral delivery.fx1 |
| Databáze: | OpenAIRE |
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