Macrocyclic Scaffold for the Collagen Triple Helix
| Autor: | Qian Zhao, Steven D. Burke, Ronald T. Raines, Eric S Benedict, Andrew J Hawk, Jia-Cherng Horng |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Models
Molecular Scaffold Molecular Structure Protein Conformation Chemistry Collagen helix Organic Chemistry Biochemistry Folding (chemistry) Crystallography Protein structure Covalent bond Thermodynamics Molecule Amino Acid Sequence Collagen Physical and Theoretical Chemistry Peptide sequence Triple helix |
| Zdroj: | Organic Letters. 8:4735-4738 |
| ISSN: | 1523-7052 1523-7060 |
| Popis: | [structure: see text] Three strands of natural collagen are linked by covalent bonds prior to their folding into a triple helix. We report on a synthetic collagen in which the strands are pendent on a rigid macrocyclic scaffold of C(3) symmetry. The scaffold confers substantial conformational stability upon the collagen triple helix and makes its folding independent of concentration, both desirable attributes for exploring and exploiting synthetic collagens. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|