Neuromyelitis optica: phenotypic characteristics in a Brazilian case series
| Autor: | Regina Maria Papais-Alvarenga, Patricia Beatriz Christino Marinho, Maria Cristina Del Negro |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Adult Male Pediatrics medicine.medical_specialty Adolescent Cross-sectional study neuromyelitis optica cross-sectional studies ensaio enzimático Enzyme-Linked Immunosorbent Assay neuromielite óptica Transverse myelitis lcsh:RC321-571 03 medical and health sciences Young Adult 0302 clinical medicine Epidemiology estudo transversal Medicine Humans NMO Spectrum Disorders Young adult epidemiologia Child lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Aged Autoantibodies Retrospective Studies Aquaporin 4 Neuromyelitis optica business.industry Neuromyelitis Optica Retrospective cohort study Middle Aged medicine.disease 030104 developmental biology Phenotype Neurology Child Preschool Female epidemiology Neurology (clinical) sense organs enzyme-linked immunosorbent assay business 030217 neurology & neurosurgery |
| Zdroj: | Arquivos de Neuro-Psiquiatria v.75 n.2 2017 Arquivos de neuro-psiquiatria Academia Brasileira de Neurologia instacron:ABNEURO Arquivos de Neuro-Psiquiatria, Vol 75, Iss 2, Pp 81-86 Arquivos de Neuro-Psiquiatria, Volume: 75, Issue: 2, Pages: 81-86, Published: FEB 2017 |
| Popis: | The definition of neuromyelitis optica (NMO) is still evolving. In 2015, the International Panel for NMO Diagnosis was convened to develop revised diagnostic criteria. There have been few studies on NMO in the Brazilian population. Objective To describe the characteristics of 34 Brazilian NMO patients. To evaluate the contribution of the 2015 criteria to the diagnosis of NMO spectrum disorders (NMOSD) in 40 patients with longitudinal extensive transverse myelitis (LEMT). Methods This is a retrospective, descriptive and analytic study. Results Among NMO patients, there was a predominance of women, with onset in the fourth decade of life, and AQP4-IgG seropositivity in 73.5%. The diagnosis of NMOSD was established in 37.5% of LETM patients according to AQP4-IgG positivity and in 5% of LETM patients if the AQP4-IgG result was unknown. Conclusions The characteristics of this series are similar to those of other Western populations. The AQP4-IgG testing assists in the diagnosis of NMOSD. RESUMO Neuromielite óptica (NMO) é um conceito em evolução. Em 2015, o Painel Internacional para o diagnóstico de NMO apresentou novos critérios diagnósticos. Poucos são os estudos em NMO na população brasileira. Objetivos Descrever as características de 34 casos brasileiros de NMO. Avaliar a contribuição dos critérios de 2015 para o diagnóstico de desordens do espectro NMO em 40 pacientes com mielite transversa longitudinal extensa (MTLE). Métodos Estudo retrospectivo, descritivo e analítico. Resultados Predomínio do sexo feminino, início na quarta década e anticorpo anti-AQP4 positivo em 73,5% dos casos de NMO. Diagnóstico de desordem do espectro NMO estabelecido em 37.5% dos casos de MTLE com positividade do anticorpo anti-AQP4 e em 5% se o resultado sorológico fosse desconhecido. Conclusões Esta série de casos de NMO tem características semelhantes às de outras séries ocidentais. A pesquisa do anticorpo anti-AQP4 é relevante para o diagnóstico das desordens do espectro da NMO. |
| Databáze: | OpenAIRE |
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