A Synthetic Approach to Pyrazolopyranopyrimidinones and Pyrazolopyranooxazinones as Antimicrobial Agents
| Autor: | Hamed A. Derbala, Ghada Bassioni, A. M. A. Hassan, M. S. Abdel-Aziz, Ahmed K. El-Ziaty |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
chemistry.chemical_classification
Article Subject 010405 organic chemistry Oxazines General Chemistry 010402 general chemistry Antimicrobial 01 natural sciences Combinatorial chemistry 0104 chemical sciences lcsh:Chemistry Acylation Pyrimidinones lcsh:QD1-999 chemistry Organic chemistry Spectral data |
| Zdroj: | Journal of Chemistry, Vol 2016 (2016) |
| ISSN: | 2090-9071 2090-9063 |
| DOI: | 10.1155/2016/5286462 |
| Popis: | The hitherto unknown 6-amino-4-(2-chloro-5-nitrophenyl)-3-methyl-1,4-dihydropyrano[2,3-c] pyrazole-5-carbonitrile1awas synthesized. Both1aand its 2,4 dichlorophenyl derivative1bwere utilized as building blocks for the preparation of novel class of pyrazolopyrano-[oxazines2a–dand pyrimidinones3a–d]. Synthesis of these compounds was achieved by two alternative acylation steps followed by ammonolysis. The structures of the synthesized compounds were elucidated by spectral data and elemental analysis. Screening and evaluation of these products as antimicrobial agents showed that the derivatives1b,2s,3b, and3dpossess a potent activity. |
| Databáze: | OpenAIRE |
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