Pulmonary cryptococcosis in non-AIDS patients
| Autor: | Richard W. Light, Kejing Tang, Bing-ling Xu, Jin-quan Yu, Canmao Xie |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Microbiology (medical)
Adult Male medicine.medical_specialty Antifungal Agents Clinical presentation medicine.medical_treatment Antifungal drug lcsh:QR1-502 Asymptomatic lcsh:Microbiology lcsh:Infectious and parasitic diseases Pneumonectomy Young Adult Diagnosis medicine Thoracoscopy Humans Pulmonary cryptococcosis lcsh:RC109-216 Thoracotomy Fluconazole Aged Retrospective Studies Voriconazole Medicine(all) Multiple Pulmonary Nodules medicine.diagnostic_test Lung Diseases Fungal business.industry HIV negative Cryptococcosis Middle Aged Triazoles Prognosis Combined Modality Therapy Surgery Treatment Infectious Diseases Pyrimidines Cryptococcus neoformans Female medicine.symptom business Tomography X-Ray Computed medicine.drug |
| Zdroj: | Brazilian Journal of Infectious Diseases, Volume: 16, Issue: 6, Pages: 531-539, Published: DEC 2012 Brazilian Journal of Infectious Diseases, Vol 16, Iss 6, Pp 531-539 Brazilian Journal of Infectious Diseases, Vol 16, Iss 6, Pp 531-539 (2012) Brazilian Journal of Infectious Diseases v.16 n.6 2012 Brazilian Journal of Infectious Diseases Brazilian Society of Infectious Diseases (BSID) instacron:BSID |
| Popis: | Objective: To investigate the clinical features, management, and prognosis of pulmonary cryptococcosis in non-acquired immunodeficiency syndrome (AIDS) patients. Method: 24 cases of pulmonary cryptococcosis with accurate pathological diagnosis were retrospectively studied. Results: 15 male patients and nine female patients were diagnosed at the first affiliated hospital of Sun Yat-sen University from November 1999 to November 2011. The mean age at the time of diagnosis was 44.2 ± 11.3 years (range: 24 to 65 years). Among these patients, 13 had other comorbidities. 15 were symptomatic and the other nine were asymptomatic. The most common presenting symptoms were cough, chest tightness, expectoration, and fever. None had concurrent cryptococcal meningitis. The most frequent radiologic abnormalities on chest computed tomography (CT) scans were solitary or multiple pulmonary nodules, and masses or consolidations, and most lesions were located in the lower lobes. All patients had biopsies for the accurate diagnosis. Among the 24 patients, nine patients underwent surgical resections (eight had pneumonectomy via thoracotomy and one had a pneumonectomy via thoracoscopy). Five of the patients who underwent surgery also received antifungal drug therapy (fluconazole) for one to three months after the surgery. The other 15 only received antifungal drug therapy (fluconazole or voriconazole) for three to six months (five patients are still on therapy). The follow-up observation of 19 patients who had already finished their treatments lasted from two to 11 years, and there was no relapse, dissemination, or death in any of these patients. Conclusion: Non-AIDS patients with pulmonary cryptococcosis have a good prognosis with appropriate management. Keywords: Pulmonary cryptococcosis, Clinical presentation, Diagnosis, Treatment, HIV negative |
| Databáze: | OpenAIRE |
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