ADC Histogram Analysis of Cervical Cancer Aids Detecting Lymphatic Metastases-a Preliminary Study
| Autor: | Anne Kathrin Höhn, Dominik Schramm, Stefan Schob, M Exner, Hans Jonas Meyer, Nikolaos Pazaitis, Alexey Surov, Kristina Bremicker, Nikita Garnov |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Cancer Research Imaging biomarker Uterine Cervical Neoplasms 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Histogram medicine Effective diffusion coefficient Humans Radiology Nuclear Medicine and imaging Aged Cervical cancer business.industry Middle Aged medicine.disease body regions Lymphatic system Diffusion Magnetic Resonance Imaging Oncology 030220 oncology & carcinogenesis Lymphatic Metastasis Mann–Whitney U test T-stage Female Neoplasm Grading Tumor Suppressor Protein p53 Nuclear medicine business Diffusion MRI |
| Zdroj: | Molecular imaging and biology. 19(6) |
| ISSN: | 1860-2002 |
| Popis: | Apparent diffusion coefficient (ADC) histogram analysis has been used to some extent in cervical cancer (CC) to distinguish between low-grade and high-grade tumors. Although this differentiation is undoubtedly helpful, it would be even more crucial in the presurgical setting to determine whether a tumor already gained the potential to metastasize via the lymphatic system. So far, no studies investigated the potential of 3T ADC histogram analysis in CC to differentiate between nodal-positive and nodal-negative entities. Therefore, the principal aim of our study was to investigate the potential of 3T ADC histogram analysis to differentiate between CC with and without lymph node metastasis. The second aim was to elucidate possible differences in ADC histogram parameters between CC with limited vs. advanced tumor stages and well-differentiated vs. undifferentiated lesions. Finally, correlations of p53 expression and Ki-67 index with ADC parameters were analyzed. Eighteen female patients (mean age 55.4 years, range 32–79 years) with histopathologically confirmed cervical squamous cell carcinoma of the uterine cervix were prospectively enrolled. Tumor stages, tumor grading, status of metastatic dissemination, Ki67-index, and p53 expression were assessed in these patients. Diffusion weighted imaging (DWI) was obtained in a 3T scanner using the following b values: b0 and b1000 s/mm2. Group comparisons using Mann-Whitney U test revealed the following findings: nodal-positive CC had statistically significant lower ADC parameters (ADCmin, ADCmean, median ADC, Mode, p10, p25, p75, and p90) in comparison to nodal-negative CC (all p |
| Databáze: | OpenAIRE |
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