Dietary Flavonoids and Colorectal Adenoma Recurrence in the Polyp Prevention Trial
| Autor: | Amanda J. Cross, Paul S. Albert, Lisa Kahle, Peter Lance, Elaine Lanza, Jason Ashby, Gerd Bobe, Martha L. Slattery, Electra D. Paskett, Bette J. Caan, James R. Marshall, Cassandra Daston, Leah B. Sansbury, Frank Iber, James W. Kikendall, Arthur Schatzkin |
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| Rok vydání: | 2008 |
| Předmět: |
Adenoma
Adult Male medicine.medical_specialty Epidemiology Colorectal cancer Colorectal adenoma Gastroenterology Article Internal medicine medicine Humans Multicenter Studies as Topic heterocyclic compounds Prospective cohort study Aged Randomized Controlled Trials as Topic Flavonoids Chi-Square Distribution business.industry fungi food and beverages Odds ratio Middle Aged medicine.disease United States Confidence interval Logistic Models Endocrinology Oncology Female Polyp Prevention Trial Neoplasm Recurrence Local Colorectal Neoplasms business Body mass index |
| Zdroj: | Cancer Epidemiology, Biomarkers & Prevention. 17:1344-1353 |
| ISSN: | 1538-7755 1055-9965 |
| DOI: | 10.1158/1055-9965.epi-07-0747 |
| Popis: | Two recent case-control studies suggested that some flavonoid subgroups may play a role in preventing colorectal cancer. Previous prospective cohort studies generally reported no association; however, only a small subset of flavonoids was evaluated and partial flavonoid databases were used. We used the newly constructed U.S. Department of Agriculture flavonoid database to examine the association between consumption of total flavonoids, 6 flavonoid subgroups, and 29 individual flavonoids with adenomatous polyp recurrence in the Polyp Prevention Trial. The Polyp Prevention Trial was a randomized dietary intervention trial, which examined the effectiveness of a low-fat, high-fiber, high-fruit, and high-vegetable diet on adenoma recurrence. Intakes of flavonoids were estimated from a food frequency questionnaire. Multivariate logistic regression models (adjusted for age, body mass index, sex, regular non–steroidal anti-inflammatory use, and dietary fiber intake) were used to estimate odds ratios and 95% confidence intervals for both any and advanced adenoma recurrence within quartiles of energy-adjusted flavonoid intake (baseline, during the trial, and change during the trial). Total flavonoid intake was not associated with any or advanced adenoma recurrence. However, high intake of flavonols, which are at greater concentrations in beans, onions, apples, and tea, was associated with decreased risk of advanced adenoma recurrence (4th versus 1st quartile during the trial; odds ratio, 0.24; 95% confidence interval, 0.11, 0.53; Ptrend = 0.0006). Similar inverse associations were observed to a smaller extent for isoflavonoids, the flavonol kaempferol, and the isoflavonoids genistein and formononetin. Our data suggest that a flavonol-rich diet may decrease the risk of advanced adenoma recurrence. (Cancer Epidemiol Biomarkers Prev 2008;17(6):1344–53) |
| Databáze: | OpenAIRE |
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