Healing efficacy of methanol extract of leaves of Alternanthera brasiliana Kuntze in aged wound model
| Autor: | Chandana Choudhury Barua, Rumi S. Borah, D. C. Pathak, D. K. Sarma, Shameem Ara Begum |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
biology Traditional medicine integumentary system Granulation tissue wound healing Amaranthaceae biology.organism_classification Alternanthera brasiliana incision wound Surgery Hydroxyproline chemistry.chemical_compound medicine.anatomical_structure chemistry excision wound In vivo medicine biology.protein Original Article Wound healing Elastin Excision wound |
| Zdroj: | Journal of Basic and Clinical Pharmacy |
| ISSN: | 0976-0105 |
| Popis: | The methanol extract of Alternanthera brasiliana Kuntze (Family: Amaranthaceae) leaf was investigated for its wound healing effect by excision wound model (in vivo) in aged Sprague Dawley rats. In excision wound model, compared to the control group, percent contraction of wound was significantly (P < 0.01) higher in A. brasiliana-treated group (5% w/w ointment). The collagen, elastin, and hydroxyproline contents of the granulation tissue of A. brasiliana-treated group increased significantly (P < 0.01) compared to the control group, indicating better wound healing activity of the test plant. These findings were also confirmed by histopathological examination. The results suggested that methanol extract of A. brasiliana possesses significant wound healing potential in aged animal wound model. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|