Chromosomal abnormalities and atrial fibrillation and ischemic stroke incidence: a nationwide population-based study
Autor: | Jun Hwan Cho, Eue Keun Choi, Seil Oh, Myung Jin Cha, You Jung Choi, Euijae Lee, Woo Hyun Lim, In Ki Moon, Kyungdo Han, Jin Hyung Jung, Jiesuck Park, So Ryoung Lee |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
Adult
Male Down syndrome medicine.medical_specialty Adolescent lcsh:Medicine 030204 cardiovascular system & hematology Article 03 medical and health sciences Young Adult 0302 clinical medicine Internal medicine Turner syndrome medicine Humans Genetic Predisposition to Disease cardiovascular diseases Child lcsh:Science Stroke Ischemic Stroke Chromosome Aberrations Multidisciplinary Proportional hazards model business.industry Incidence (epidemiology) Incidence lcsh:R Atrial fibrillation Middle Aged medicine.disease Risk factors Ischemic stroke Female lcsh:Q Klinefelter syndrome business 030217 neurology & neurosurgery |
Zdroj: | Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020) Scientific Reports |
ISSN: | 2045-2322 |
Popis: | There is a paucity of information as to whether chromosomal abnormalities, including Down Syndrome, Turner Syndrome, and Klinefelter Syndrome, have an association with atrial fibrillation (AF) and ischemic stroke development. Data from 3660 patients with Down Syndrome, 2408 with Turner Syndrome, and 851 with Klinefelter Syndrome without a history of AF and ischemic stroke were collected from the Korean National Health Insurance Service (2007–2014). These patients were followed-up for new-onset AF and ischemic stroke. Age- and sex-matched control subjects (at a ratio of 1:10) were selected and compared with the patients with chromosomal abnormalities. Down Syndrome patients showed a higher incidence of AF and ischemic stroke than controls. Turner Syndrome and Klinefelter Syndrome patients showed a higher incidence of AF than did the control group, but not of stroke. Multivariate Cox regression analysis revealed that three chromosomal abnormalities were independent risk factors for AF, and Down Syndrome was independently associated with the risk of stroke. In conclusion, Down Syndrome, Turner Syndrome, and Klinefelter Syndrome showed an increased risk of AF. Down Syndrome patients only showed an increased risk of stroke. Therefore, AF surveillance and active stroke prevention would be beneficial in patients with these chromosomal abnormalities. |
Databáze: | OpenAIRE |
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