The acute effects of single-dose orally administered doramectin, eprinomectin and selamectin on natural infections of Syphacia muris in rats
| Autor: | Alper Sevimli, Aziz Bülbül, Nurhan Dogan, Feride Kircali Sevimli, Esma Kozan |
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| Rok vydání: | 2009 |
| Předmět: |
Male
Acute effects Veterinary medicine Immunology Administration Oral Eprinomectin Biology Rats Sprague-Dawley Rodent Diseases chemistry.chemical_compound Oxyuroidea Oral administration Animals Laboratory medicine Animals Helminths Syphacia muris Doramectin Parasite Egg Count Oxyuriasis Anthelmintics Hematologic Tests Ivermectin General Medicine Antiparasitic agent Rats Infectious Diseases Selamectin chemistry Parasitology medicine.drug |
| Zdroj: | Experimental Parasitology. 122:177-181 |
| ISSN: | 0014-4894 |
| DOI: | 10.1016/j.exppara.2009.03.008 |
| Popis: | This study was designed to determine the acute effects of a single-dose of orally administered doramectin, eprinomectin and selamectin on Syphacia muris infection in rats. Rats, naturally infected with S. muris , were divided into four groups: three different treatment groups ( n = 7) and one positive control ( n = 7). Cellophane tape preparations were obtained from the treated rats on day 0 pre-treatment and on days 2, 4 and 6 post-treatment. Syphacia sp. eggs were counted. Eprinomectin was found to be 100% effective in eliminating eggs on two post-treatment. However when egg counts on day 6 post-treatment were compared with pre-treatment egg counts, doramectin and selamectin were found to be 99.32 and 98.77% effective in eliminating eggs, respectively. On day 7 post-treatment, blood samples were obtained from all groups, and then the rats were necropsied. Doramectin, eprinomectin and selamectin were found to be 100% effective in eliminating adult S. muris , when compared with the positive control group. |
| Databáze: | OpenAIRE |
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