Structure-activity studies of quinuclidinone analogs as anti-proliferative agents in lung cancer cell lines
| Autor: | Susan C. Evans, Ahmed Malki, Aravinda B. Pulipaka, Stephen C. Bergmeier |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Quinuclidines
Lung Neoplasms Clinical Biochemistry Pharmaceutical Science Antineoplastic Agents Treatment of lung cancer Biochemistry Chemical synthesis Structure-Activity Relationship Cell Line Tumor Drug Discovery Humans Viability assay Cytotoxicity Molecular Biology Cell Proliferation Molecular Structure Cell growth Chemistry Organic Chemistry In vitro Cell culture Cancer research Molecular Medicine Radiosensitizing Agent Tumor Suppressor Protein p53 |
| Zdroj: | Bioorganicmedicinal chemistry letters. 16(5) |
| ISSN: | 0960-894X |
| Popis: | We have synthesized and tested novel quinuclidinone analogs to assay the effects on H1299 lung cancer cell lines alone or with γ-radiation. We have found two series of quinuclidinone analogs that act as anti-cancer agents. Of these, four interesting analogs significantly decreased cell viability in H1299 lung cancer cell lines. Two derivatives decreased cell proliferation in a dose-dependent fashion alone or in the presence of γ-radiation. Radiosensitization increased when derivative treatment preceded radiation treatment for both derivatives. These preliminary studies show an evidence for both additive and synergistic cytotoxicity for treatment of lung cancer by these novel quinuclidinone analogs. |
| Databáze: | OpenAIRE |
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