Feasibility and safety of 1.5 T MR-guided and daily adapted abdominal-pelvic SBRT for elderly cancer patients: geriatric assessment tools and preliminary patient-reported outcomes
| Autor: | Stefania Naccarato, Antonio De Simone, Francesco Ricchetti, Vanessa Figlia, Rosario Mazzola, Gianluisa Sicignano, Claudio Vitale, Luca Nicosia, Niccolò Giaj-Levra, Francesco Cuccia, Filippo Alongi, Ruggero Ruggieri, Michele Rigo |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine Cancer Research medicine.medical_specialty MEDLINE Radiosurgery Pelvis 03 medical and health sciences Prostate cancer 0302 clinical medicine Quality of life Surveys and Questionnaires Internal medicine Abdomen medicine Clinical endpoint Humans Patient Reported Outcome Measures Prospective Studies Prospective cohort study Geriatric Assessment Aged Aged 80 and over business.industry Radiotherapy Planning Computer-Assisted Dose fractionation Prostatic Neoplasms Cancer General Medicine medicine.disease Magnetic Resonance Imaging humanities 030104 developmental biology Oncology 030220 oncology & carcinogenesis Quality of Life Feasibility Studies Female Observational study Dose Fractionation Radiation business |
| Zdroj: | Journal of Cancer Research and Clinical Oncology. 146:2379-2397 |
| ISSN: | 1432-1335 0171-5216 |
| DOI: | 10.1007/s00432-020-03230-w |
| Popis: | We present preliminary data of the first older cancer patients treated with Hybrid Linac for stereotactic body radiotherapy (SBRT) consisting of 1.5 T MRI-guided and daily-adapted treatment. The aim was to assess feasibility, safety and the role of G8 and Charlson Comorbidity Index (CCI) questionnaires in predicting patients’ QoL, evaluated by patient-reported outcome measures (PROMs). Two groups of patients with localized prostate cancer or abdominal-pelvic oligometastases were analyzed. SBRT schedule consisted of 35 Gy delivered in 5 fractions. The primary endpoint was to measure the impact of G8 and CCI on PROMs. Both G8 and the CCI were performed at baseline, while the EORTC Quality of Life Questionnaire-Core 30 (EORTC QLQ-C30) for PROMs assessment was prospectively performed at baseline and after SBRT. Forty older patients were analyzed. The median age was 73 years (range 65–85). For the entire population, the median G8 score was 15 (10–17) and the median CCI score was 6 (4–11). Concerning the PROMS, the EORTC-QLQ C30 questionnaire reported no difference between the pre- and post-SBRT evaluation in all patients, except for the fatigue item that declined after SBRT, especially in the group of patients with a G8 score |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink