Anterior cingulate cortex volume reduction in patients with panic disorder

Autor:	Yoshio Hirayasu, Namiko Nihashi, Fumi Hayano, Tatsui Otsuka, Hidenori Yamasue, Motoaki Nakamura, Tomio Inoue, Takeshi Asami, Tomohide Roppongi, Kumi Uehara
Rok vydání:	2008
Předmět:	Adult Male Cingulate cortex medicine.medical_specialty Statistics as Topic Gyrus Cinguli behavioral disciplines and activities Neuroimaging Reference Values Functional neuroimaging Internal medicine mental disorders Image Processing Computer-Assisted medicine Humans Dominance Cerebral Anterior cingulate cortex Brain Mapping General Neuroscience Panic disorder Panic General Medicine Voxel-based morphometry Middle Aged medicine.disease Magnetic Resonance Imaging stomatognathic diseases Psychiatry and Mental health medicine.anatomical_structure nervous system Neurology Cardiology Panic Disorder Female Neurology (clinical) medicine.symptom Psychology Neuroscience psychological phenomena and processes Anxiety disorder
Zdroj:	Psychiatry and Clinical Neurosciences. 62:322-330
ISSN:	1440-1819 1323-1316
DOI:	10.1111/j.1440-1819.2008.01800.x
Popis:	Aim: Recent neuroimaging studies have suggested that the anterior cingulate cortex (ACC) has an important role in the pathology of panic disorder. Despite numerous functional neuroimaging studies that have elucidated the strong relationship between functional abnormalities of the ACC and panic disorder and its symptoms and response to emotional tasks associated with panic disorder, there has been no study showing volumetric changes of the ACC or its subregions. Methods: To clarify the structural abnormalities of ACC and its subregions, the combination of region of interest (ROI) and optimized voxel-based morphometry (VBM) methods were performed on 26 patients with panic disorder, and 26 age and sex-matched healthy subjects. In the ROI study, ACC was divided into four subregions: dorsal, rostral, subcallosal and subgenual ACC. Results: The results of the manually traced ROI volume comparison showed significant volume reduction in the right dorsal ACC. VBM also showed a volume reduction in the right dorsal as well as a part of the rostral ACC as a compound mass. Conclusions: Both manual ROI tracing and optimized VBM suggest a subregion-specific pattern of ACC volume deficit in panic disorder. In addition to functional abnormalities, these results suggest that structural abnormalities of the ACC contribute to the pathophysiology of panic disorder.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::884dff0f710cc0893a4c4909d59b7e3a https://doi.org/10.1111/j.1440-1819.2008.01800.x Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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