| Autor: |
GJ Elfenbein, DS Brogaonkar, WB Bias, WH Burns, R Saral, LL Sensenbrenner, PJ Tutschka, BS Zaczek, AR Zander, RB Epstein, JD Rowley, GW Santos |
| Rok vydání: |
1978 |
| Předmět: |
|
| Zdroj: |
Blood. 52(3) |
| ISSN: |
0006-4971 |
| Popis: |
A 22-yr-old man with acute myelocytic leukemia received a bone marrow transplant from a genotypically HLA-identical female sibling after cyclophosphamide preparation. He remained in complete remission for 18 mo, when he developed a chloroma in the perineum. The chloroma was treated with local radiotherapy. The chloroma recurred 8 mo later and was treated with radiotherapy followed by combination chemotherapy. At 34 mo after transplant, marrow relapse and chloroma were documented. The first chloroma contained host cells by fluorescent Y-chromatin body analyses of interphase nuclei. All metaphase cells and karyotypes from peripheral blood and marrow samples showed no evidence of host cells from 3 wk after transplant through the time of marrow relapse. Data from autosomal and sex chromosome studies indicate that the marrow relapse occurred in cells of donor origin. A new consistent chromosome abnormality [45, X, -X, t(8;21) (q22; q22)] was observed in a majority of donor cells. The patient received a second bone marrow transplant from the same donor after preparation with busulfan and cyclophosphamide and attained a complete remission with full hematologic engraftment. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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